Serum Levels of Zinc, Copper and Ferritin in Patients with Salivary Gland Tumors

Document Type : Research Articles


1 Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.

3 Institute of Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.


Background: Variation in serum levels of trace elements including zinc, copper and ferritin has been reported in
cancer patients. The aim of this study was to evaluate these trace elements in the patients’ sera with benign and malignant
salivary gland tumors (SGTs) and compare them with normal individuals. Methods: In this cross-sectional study, 60
patients with SGTs including 16 pleomorphic adenoma and 44 malignant SGTs, as well as 28 healthy controls, were
enrolled. Serum levels of zinc, copper and ferritin were determined by atomic absorption and ELISA methods. Data
were analyzed using one way ANOVA, Chi-square, Kruskal-Wallis and Mann- Whitney tests. Results: The mean
concentration of zinc, copper, ferritin was1.5± 2 ppm, 1.2± 0.5 ppm, and 96.7± 65.7 ng/ml in PA, 1.5± 1.4,1.3± 0.4,
and 111.2± 112 in malignant SGTs, and1.1±0.3, 1.2± 0.23 and 124±135.8 in normal control groups. There was no
statistically significant difference between the patients and control groups, and between benign and malignant SGTs
(P>0.05). Conclusion: The serum levels of trace elements in SGTs were not different from normal individuals. The
results might have been affected by some interventional factors. Therefore, designing cohort complementary studies
might result in obtaining more accurate data.


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