Document Type : Systematic Review and Meta-analysis
Authors
1
Doctoral Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta City, Indonesia.
2
Department of Public Health, Faculty of Medicine, Universitas Andalas, Padang City, Indonesia.
3
Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta City, Indonesia.
4
Department of Health Policy and Management, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta City, Indonesia.
5
Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta City, Indonesia.
Abstract
Objective: This systematic review and meta-analysis was performed to determine the protective effect of omega-3
fatty acids in fish consumption against breast cancer in Asian patients. Methods: The authors conducted a meta-analysis
of published research articles on protective effect of omega-3 fatty acids in fish consumption against breast cancer in
Asian patients published between January 2000 and July 2018 in online database of PubMed, ProQuest and EBSCO.
Pooled odds ratios (OR) were calculated by using fixed and random-effect models. Publication bias was visually
evaluated by using funnel plots and statistically assessed in Egger’s and Begg’s tests. Data were processed by Review
Manager 5.3 (RevMan 5.3) and Stata version 14.2 (Stata Corporation). Results: This study reviewed 913 articles.
There were 11 studies which conducted systematic review then continued by meta-analysis of relevant data with total
number of samples were 130,365 patients. The results showed there was protective effect of omega-3 fatty acids in fish
consumption against breast cancer in Asian patients (OR = 0.80 [95% CI 0.73-0.87, p <0.00001]). There was not any
study with significant publication bias included. Conclusion: This analysis confirmed the protective effect of omega-3
fatty acids in fish consumption against breast cancer in Asian patients.
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