Antioxidant and Cytotoxicity Activities of Karamunting (Melastoma malabathricum L.) Fruit Ethanolic Extract and Quercetin

Document Type : Research Articles


Department of Pharmacology and Therapeutics, Faculty of Medicine, Lambung Mangkurat University, South Kalimantan, Indonesia.


Melastoma malabathricum L. is a type of plant naturally grows in Kalimantan that has medicinal properties.
Ethanolic extract of M. malabathricum L. flower has quercetin and kaempferol contents that have antioxidant and
anticancer activities. But the antioxidant and cytotoxicity activities of M. malabathricum L. fruit ethanolic extract were
not known. This study measured the quercetin and kaempferol level in M. malabathricum L. fruit ethanolic extract
using HPLC MS/MS, antioxidant activity using DPPH method, and cytotoxicity activity using Brine Shrimp Lethality
Test (BSLT) method. Results showed the level of quercetin and kaempferol from M. malabathricum L fruit ethanolic
extract are 67.78 μg/g and 43.52 μg/g, respectively. Beside, the antioxidant activity with by IC50 was 16.82±0.24 ppm
and 7.38±0.41 ppm. The cytotoxicity activities of M. malabathricum L. fruit ethanolic extract and quercetin are shown
by the LC50 of 313.44 ppm (95%CI 283.97-344.43) and 37.24 ppm, respectively.


Main Subjects

Volume 20, Issue 2
February 2019
Pages 639-643
  • Receive Date: 23 October 2018
  • Revise Date: 02 January 2019
  • Accept Date: 02 February 2019
  • First Publish Date: 02 February 2019