Impact of Coexisting Uterine Adenomyosis on the Survival Outcome of Patients with Endometrial Cancer: A Retrospective Cohort Study

Boonlak, Sarana; Aue-Aungkul, Apiwat; Kietpeerakool, Chumnan; Kleebkaow, Pilaiwan; Chumworathayi, Bandit; Luanratanakorn, Sanguanchoke; Temtanakitpaisan, Amornrat

doi:10.31557/APJCP.2019.20.4.1185

Impact of Coexisting Uterine Adenomyosis on the Survival Outcome of Patients with Endometrial Cancer: A Retrospective Cohort Study

Document Type : Research Articles

Authors

Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Thailand.

10.31557/APJCP.2019.20.4.1185

Abstract

Objective: To determine the effects of uterine adenomyosis on endometrial cancerrecurrence rates. Methods: This
retrospective cohort study reviewed all consecutive patients diagnosed with endometrial cancerwho underwent total
hysterectomy-based surgical staging at Srinagarind Hospital between January, 2010 and January, 2016. The patientswere
divided into two groups:a uterine adenomyosisgroup and a non-adenomyosis group. Patient demographics, type of
surgery, histopathology, stage of endometrial cancer, adjuvant treatment, and survival outcomes were compared.
Results: A total 350 patients were enrolled, with 132 (37.71%) in the adenomyosis group and 218 (62.29%) in the nonadenomyosis group. Deep myometrial invasion and lymphovascular space invasion (LVSI) were more commonly found
among patients who had no adenomyosis compared to those with adenomyosis(52.8% vs 39.4%, P=0.02 and 53.2%
vs. 38.6%, P=0.01). There were no significant differences in terms of five-year recurrence-free survival (HR=1.47;
95%CI 0.88-2.44) and five-year overall survival (HR=0.81; 95%CI 0.43-1.53) between the two comparison groups.
Conclusion: Coexisting uterine adenomyosis in endometrial cancer wasassociated withdeep myometrial invasion and
LVSI but did not have significant impact on survival.

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