Examination of Diagnostic Accuracy of UroVysion Fluorescence In Situ Hybridization for Bladder Cancer in a Single Community of Japanese Hospital Patients

Document Type : Research Articles


1 Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.

2 Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, Japan.


Objective: UroVysion (Abbott Molecular, Inc., Illinois, USA) is based on multicolor fluorescence in situ hybridization
(FISH). It has been used successfully in the USA following its Food and Drug Administration approval in 2001. However,
the technology was not approved for use in Japan until 2017. Cystoscopy and urine cytology are the most frequently
used examinations to detect bladder cancer in Japan, and there are only a few reports regarding the performance of
UroVysion. Therefore, the aim of this study is to examine the diagnostic accuracy of UroVysion FISH in Japanese
patients whose tumors are detected by cystoscopy before transurethral resection of bladder tumor (TURBT). Methods:
From April 2018 to July 2018, a total of 40 patients who were diagnosed as having bladder tumors by cystoscopy, and
therefore underwent TURBT were registered in this study. One day before TURBT, urine cytology and UroVysion
FISH were used in order to compare the accuracy with which they could detect bladder carcinoma, as confirmed by
pathological results of TURBT. Results: The pathological results of TURBT showed urothelial carcinoma in 33 cases.
Urine cytology showed positive results for 0 cases (0%), suspicious results for 10 cases (30.3%), and negative results
for 23 cases (69.7%). On the other hand, UroVysion FISH indicated 9 positive cases (27.3%) and 24 negative cases
(72.7%). There were 19 cases of urothelial carcinoma (57.6%) that were not detected by either method. Conclusion:
We conclude that UroVysion FISH alone is insufficient to detect bladder cancer and that cystoscopy is essential for the
optimum detection or follow up of bladder cancer cases in our hospital.


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