The Relationship between the Serum Level of Selenium and Cervical Intraepithelial Neoplasia: A Comparative Study in a Population of Nigerian Women

Document Type : Research Articles


1 Nisa Premier Hospital, Abuja, Nigeria.

2 Department of Obstetrics and Gynaecology, University of Benin Teaching Hospital, Benin City, Edo state, Nigeria.


Objective: To determine the relationship between the serum level of selenium and cervical intraepithelial neoplasia
(CIN). Methods: A case controlled study that compared the serum level of selenium in 45 women with CIN (cases) to
45 women (age matched controls) with normal cervical cytology. Socio-demographic data and information on known
risk factors for cervical cancer among the sample was compared between both groups using inferential statistics.
Results: There was no significant difference in the mean selenium values between the cases and controls [p- 0.076,
95% CI (-15.08 – 0.76)]. However, subgroup analysis showed a statistically significant difference between patients
with normal cervical cytology, CIN I, II and III (p= 0.021). In addition, there was also significant difference in the
selenium level between women with normal cervical cytology and CIN III (p value = 0.016) with a significant inverse
linear trend (p= 0.025). Conclusion: With increasing severity of CIN, a significant reduction in the level of selenium
in serum was observed. This reducing value of serum selenium, a surrogate marker for increased oxidative stress, may
be important factor for the development of persistent HPV infection and in particular high grade CIN III lesions. This
observation requires further research.


Main Subjects