Effect of the Walking Exercise Program on Cancer-Related Fatigue in Patients with Acute Myeloid Leukemia Undergoing Chemotherapy

Document Type : Research Articles


1 Nursing Care Research Center in Chronic Diseases, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 School of Rehabilitation, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

4 Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.


Background: Cancer-related Fatigue (CRF) is one of the most common complications of acute myeloid leukemia
(AML) and its related therapies. It can influence all physical and psychological aspects of the patient’s life. Also, it
is believed that exercise can improve CRF in patients with cancer. Objective: This study aimed to investigate the
effect of the walking exercise program on CRF in patients with AML undergoing chemotherapy. Methods: In this
quasi-experimental study with a pre- and post-test design, 50 patients with AML undergoing chemotherapy were
selected using a convenience sampling method at a teaching hospital in an urban area of Iran. The intervention included
daily 30 minutes of planned walking for ten days. Data was collected using a demographic data form and the Brief
Fatigue Inventory, which were filled out before the intervention, and on the fifth and tenth days of the intervention.
Findings: Statistically significant differences were reported in the reduction of CRF on the fifth day and tenth day
of the intervention (p <0.001). Conclusions: The planned walking intervention can be used as an easy and low-cost
method for reducing CRF in patients with leukemia.


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