Background: The key proliferative RTKs for AML include c-KIT receptor (CD117) and FLT-3 receptor (CD135). The aim of this study was to evaluate the CD135 and CD117 expression, co-expression of CD135 and CD117 (CD135+CD117), and the association of that co-expression with Event Free Survival (DFS) and Overall Survival (OS) rates. Material and Methods: We analyzed CD117 and CD135 expression on AML blasts by flow cytometry and its association with Event Free Survival (DFS) and Overall Survival (OS) in 66 AML treated on Hematology-Oncology Research Center, Iran, Tabriz. Results: The overall OS and EFS were 50% and 80.3% respectively during our study. Cox-regression analysis revealed that a poor EFS was significantly associated a low CD135 (HR 0.34, 95% CI 0.13–0.88, P = 0.02). Conclusion: This is the first study from Iran to show that the expressions of CD135, CD117 is easily measurable by routine diagnostic flow-cytometry, and CD135+117 were not significantly associated with CR, EFS, or OS .
Raeisi, M., Nikhanfar, A. R., Nejate, B., Movassaghpour Akbari, A. A., Dolatkhah, R., Roosta, Y., & Sanaat, Z. (2019). Role of CD135/CD117 on Prognosis and Overall Survival of Acute Myeloid Leukemia. Asian Pacific Journal of Cancer Prevention, 20(9), 2625-2631. doi: 10.31557/APJCP.2019.20.9.2625
MLA
Mortaza Raeisi; Ali Reza Nikhanfar; Babak Nejate; Ali Akabr Movassaghpour Akbari; Roya Dolatkhah; Yousef Roosta; Zohreh Sanaat. "Role of CD135/CD117 on Prognosis and Overall Survival of Acute Myeloid Leukemia". Asian Pacific Journal of Cancer Prevention, 20, 9, 2019, 2625-2631. doi: 10.31557/APJCP.2019.20.9.2625
HARVARD
Raeisi, M., Nikhanfar, A. R., Nejate, B., Movassaghpour Akbari, A. A., Dolatkhah, R., Roosta, Y., Sanaat, Z. (2019). 'Role of CD135/CD117 on Prognosis and Overall Survival of Acute Myeloid Leukemia', Asian Pacific Journal of Cancer Prevention, 20(9), pp. 2625-2631. doi: 10.31557/APJCP.2019.20.9.2625
VANCOUVER
Raeisi, M., Nikhanfar, A. R., Nejate, B., Movassaghpour Akbari, A. A., Dolatkhah, R., Roosta, Y., Sanaat, Z. Role of CD135/CD117 on Prognosis and Overall Survival of Acute Myeloid Leukemia. Asian Pacific Journal of Cancer Prevention, 2019; 20(9): 2625-2631. doi: 10.31557/APJCP.2019.20.9.2625
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