Association between SNPs and Loss of Methylation Site on the CpG island of the Promoter Region of the Smoothened Gene, Potential Molecular Markers for Susceptibility to the Development of Basal Cell Carcinoma in the Brazilian Population

Document Type : Research Articles

Authors

• Augusto Monteiro de Souza ^{1, 2}
• Otávio Sérgio Lopes ^{3, 4}
• Andressa de Lima Liberato ^{1, 2}
• Paulo Junior Ribeiro de Oliveira ^{1, 2}
• Sylvia Satomi Takeno Herrero ¹
• Agnaldo Luiz do Nascimento ^{1, 2}
• Carlos Alberto Longui ⁴
• Ivan Rodrigues de Carvalho Filho ⁵
• Leonardo Ferreira Soares ⁶
• Renally Barbosa da Silva ⁷
• Rommel Rodriguez Burbano ⁸
• Plínio Delatorre ^{1, 2, 9}
• Eleonidas Moura Lima ^{1, 2, 9}

¹ Laboratory of Structural Molecular Biology and Oncogenetics - LBMEO, Federal University of Paraiba, João Pessoa - PB, Brazil.

² Postgraduate Program in Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa - PB, Brazil.

³ Department of Dermatology, Dermatological Clinic Santa Catarina, João Pessoa - PB - Brazil.

⁴ Postgraduate Program in Health Sciences; Santa Casa School of Medical Sciences of São Paulo; Sao Paulo – SP, Brazil.

⁵ Depathology of Pathology, Laboratory of Medical Analysis - UNILAB, João Pessoa - PB, Brazil.

⁶ 6Pharmacy Department; State University of Paraíba; Campina Grande – PB, Brazil.

⁷ Postgraduate Program in Natural Sciences and Biotechnology, Federal University of Campina Grande - UFCG, Campus de Cuité – PB, Brazil.

⁸ Institute of Biological Sciences; Federal University of Pará; Belém - PA - Brazil Brazil.

⁹ Molecular Biology Department; Federal University of Paraiba; João Pessoa - PB, Brazil.

Abstract

Keywords

• Basal Cell Carcinoma
• CpG-SNPs
• via Hedgehog
• molecular markers e DSAPS

Main Subjects

• Cancer biology