Background: Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory breast condition with unknown etiology. Different treatments including corticosteroids have been recommended with no universal consensus. In this study we evaluated the efficacy of low dose vs. high dose prednisolone in treatment of IGM. Methods: In this randomized clinical trial, 30 female patients with IGM were randomly allocated to receive low dose or high dose prednisolone. First group received 5 mg daily prednisolone, while the second group received 50 mg for three days, 25 mg for the next three days and then 12.5 mg for further three days and 5 mg daily afterwards, both for two months. Patients were evaluated 2, 3, 6 and 12 months after treatment. The success and recurrence rate was compared between groups. Results: High dose group had significantly higher rate of remission compared to low dose group (93.3% vs. 53.3%, p=0.03). One patient in high dose group and 5 patients in low dose group underwent lumpectomy due to persistent symptoms. Two other patients in low dose group received high dose treatment after three months due to no change in symptoms. Among patients with remission, recurrence was also significantly lower in high dose compared to low dose prednisolone (0% vs. 37.5%, p=0.04). Conclusion: High dose prednisolone has high success rate with lower recurrence in the treatment of IGM and could reduce the need for surgery. However, further studies are necessary to confirm these findings.
Montazer, M., Dadashzadeh, M., & Moosavi Toomatari, S. E. (2020). Comparison of the Outcome of Low Dose and High-Dose Corticosteroid in the Treatment of Idiopathic Granulomatous Mastitis. Asian Pacific Journal of Cancer Prevention, 21(4), 993-996. doi: 10.31557/APJCP.2020.21.4.993
MLA
Majid Montazer; Maryam Dadashzadeh; Seyed Ehsan Moosavi Toomatari. "Comparison of the Outcome of Low Dose and High-Dose Corticosteroid in the Treatment of Idiopathic Granulomatous Mastitis". Asian Pacific Journal of Cancer Prevention, 21, 4, 2020, 993-996. doi: 10.31557/APJCP.2020.21.4.993
HARVARD
Montazer, M., Dadashzadeh, M., Moosavi Toomatari, S. E. (2020). 'Comparison of the Outcome of Low Dose and High-Dose Corticosteroid in the Treatment of Idiopathic Granulomatous Mastitis', Asian Pacific Journal of Cancer Prevention, 21(4), pp. 993-996. doi: 10.31557/APJCP.2020.21.4.993
VANCOUVER
Montazer, M., Dadashzadeh, M., Moosavi Toomatari, S. E. Comparison of the Outcome of Low Dose and High-Dose Corticosteroid in the Treatment of Idiopathic Granulomatous Mastitis. Asian Pacific Journal of Cancer Prevention, 2020; 21(4): 993-996. doi: 10.31557/APJCP.2020.21.4.993
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