Objective: The present study aimed to investigate the impact of preoperative C-reactive protein to albumin (CRP/Alb) ratio on the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC). Methods: 82 patients who underwent hepatic resection for mass-forming type of ICC were evaluated. The relationship between preoperative CRP/Alb ratio and survival outcomes was investigated. Results: The optimal cutoff value of CRP/Alb ratio for assessing overall survival (OS) was determined as 0.089. Univariate analysis for recurrence-free survival (RFS) showed that CRP/Alb ratio >0.089, carbohydrate antigen 19-9 (CA 19-9) >37 U/mL, lymph node metastasis, vascular invasion, and multiple tumors were significantly associated with postoperative recurrence. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.006), and multiple tumors (p < 0.001). Univariate analysis for OS showed that CRP/Alb ratio >0.089, CA 19-9 >37 U/mL, lymph node metastasis, vascular invasion, multiple tumors, and positive surgical margin were significantly associated with overall death. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.01), and multiple tumors (p = 0.005). Conclusion: Preoperative CRP/Alb ratio may predict poor long-term outcomes after hepatic resection in patients with ICC.
Ito, T., Shinkawa, H., Takemura, S., Tanaka, S., Nishioka, T., Miyazaki, T., Ishihara, A., & Kubo, S. (2020). Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma. Asian Pacific Journal of Cancer Prevention, 21(8), 2373-2379. doi: 10.31557/APJCP.2020.21.8.2373
MLA
Tokuji Ito; Hiroji Shinkawa; Shigekazu Takemura; Shogo Tanaka; Takayoshi Nishioka; Toru Miyazaki; Atsushi Ishihara; Shoji Kubo. "Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma". Asian Pacific Journal of Cancer Prevention, 21, 8, 2020, 2373-2379. doi: 10.31557/APJCP.2020.21.8.2373
HARVARD
Ito, T., Shinkawa, H., Takemura, S., Tanaka, S., Nishioka, T., Miyazaki, T., Ishihara, A., Kubo, S. (2020). 'Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma', Asian Pacific Journal of Cancer Prevention, 21(8), pp. 2373-2379. doi: 10.31557/APJCP.2020.21.8.2373
VANCOUVER
Ito, T., Shinkawa, H., Takemura, S., Tanaka, S., Nishioka, T., Miyazaki, T., Ishihara, A., Kubo, S. Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma. Asian Pacific Journal of Cancer Prevention, 2020; 21(8): 2373-2379. doi: 10.31557/APJCP.2020.21.8.2373
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