Association between Angiotensin-Converting Enzyme- Insertion/Deletion Polymorphism and Diabetes Mellitus-2 in Saudi Population

Document Type : Research Articles


1 Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Jazan University, Saudi Arabia.

2 Department of Medicine, University Of Cambridge, United Kingdom.

3 Massachusetts General Hospital Cancer Centre, Harvard Medical School, USA.

4 Emergency Medical Services, Jazan University, Saudi Arabia.

5 King Fahad Medical City, Riyadh, Saudi Arabia.


Objectives: The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the development of type 2 diabetes mellitus (T2DM) has been debated vigorously but still remains controversial. Therefore, the current study was designed to determine the possible association between ACE I/D polymorphism and T2DM and hypertension (HTN) in a population of Saudi Arabian participants. Methods: A total of 143 individuals were recruited for the study, consisting of 74 controls and 69 patients with T2DM. Genotyping was performed via polymerase chain reaction. Results: The genotype frequencies for DD, ID and II in controls were 52.7%, 39.2% and 8.1%, whereas in T2D patients it was 52.2%, 40.6% and 7.2% respectively. The DD frequency was highest out of the three genotypes in both the controls and the T2DM patients. Conclusion: There was no significant difference found in the genotype and allele frequencies between cases and controls, suggesting that insertion/deletion polymorphism in the ACE gene may not be associated with an increased susceptibility to type 2 diabetes in our study population.


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