Objective: The present report investigated the rates of coinfections between high-rik human papillomavirus (hrHPV) and the most important human mycoplasmas including Mycoplasma hominis, M. genitalium, Ureaplasma urealyticum and U. parvum in cervical samples of asymptomatic brazilian population. Methods: Were included a total of 283 women aged 25–64 years screened by Papanicolaou smears for determining cervical abnormalities, single-target polymerase chain reaction (PCR) and real-time PCR (rt-PCR) for hrHPV and mycoplasmas, respectively. Results: A total of 273 (94.5%) women were negative for intraepithelial lesions or malignancy cytology (NILM) and 10 (3.5%) presented abnormal cytology, all low-grade intraepithelial lesions (LSIL). The prevalence of hrHPV was 12.7% and 53.7% for mycoplasmas. U. parvum was the most frequently bacteria detected, followed by Mycoplasma hominis and U. urealyticum. M. genitalium was not detected. Women positive for U. parvum presented a 5-fold increased risk of LSIL (OR = 5.33; 95% CI = 1.09-26.04, P = 0.02) and co-infections between U. parvum and hrHPV increased the risk for LSIL (OR = 3.88; 95% CI = 1.75-8.58, P = 0.0003). However, these associations were not dependent on the concentration of the bacteria. Conclusion: Our results reinforced the hypothesis that some mycoplasmas may play a role as cofactors in HPV-mediated cervical carcinogenesis, at least in some populations.
Noma, I., Shinobu-Mesquita, C., Suehiro, T., Morelli, F., de Souza, M., Damke, E., da Silva, V., & Consolaro, M. (2021). Association of Righ-Risk Human Papillomavirus and Ureaplasma parvum Co-Infections with Increased Risk of Low-Grade Squamous Intraepithelial Cervical Lesions. Asian Pacific Journal of Cancer Prevention, 22(4), 1239-1246. doi: 10.31557/APJCP.2021.22.4.1239
MLA
Isabella Harumi Yonehara Noma; Cristiane Suemi Shinobu-Mesquita; Tamy Taianne Suehiro; Fabricio Morelli; Maria Vitória Felipe de Souza; Edilson Damke; Vânia Ramos Sella da Silva; Marcia Edilaine Lopes Consolaro. "Association of Righ-Risk Human Papillomavirus and Ureaplasma parvum Co-Infections with Increased Risk of Low-Grade Squamous Intraepithelial Cervical Lesions". Asian Pacific Journal of Cancer Prevention, 22, 4, 2021, 1239-1246. doi: 10.31557/APJCP.2021.22.4.1239
HARVARD
Noma, I., Shinobu-Mesquita, C., Suehiro, T., Morelli, F., de Souza, M., Damke, E., da Silva, V., Consolaro, M. (2021). 'Association of Righ-Risk Human Papillomavirus and Ureaplasma parvum Co-Infections with Increased Risk of Low-Grade Squamous Intraepithelial Cervical Lesions', Asian Pacific Journal of Cancer Prevention, 22(4), pp. 1239-1246. doi: 10.31557/APJCP.2021.22.4.1239
VANCOUVER
Noma, I., Shinobu-Mesquita, C., Suehiro, T., Morelli, F., de Souza, M., Damke, E., da Silva, V., Consolaro, M. Association of Righ-Risk Human Papillomavirus and Ureaplasma parvum Co-Infections with Increased Risk of Low-Grade Squamous Intraepithelial Cervical Lesions. Asian Pacific Journal of Cancer Prevention, 2021; 22(4): 1239-1246. doi: 10.31557/APJCP.2021.22.4.1239
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