Background: In this study, we aimed to detect Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) frequency in paragangliomas and pheochromocytomas (PPGL) with immunohistochemistry; compare with Pheochromacytoma of the Adrenal Gland Scaled Score (PASS) classification and analyse the differences between pheochromocytoma (Pheo), head-neck paragangliomas (HNPGL) and thoraco-abdominal-pelvic paraganglioma (TAPPGL) sub-groups. Methods: A total 114 PPGL cases (73 HNPGL, 15 TAPPGL and 27 Pheo belonging to 112 cases) are included. Immunohistochemically, SDHB and Ki-67 are investigated and malignancy risks are determined by PASS classification. Results are assessed statistically with chi-square test and p <0,01 is considered significant.Results: SDHB mutations are observed in 20 of 114 (17.54 %) PPGL cases, 3 (11,12%) of which is Pheo, 12 (16,44) is HNPGL, and 5 (35,71%) is TAPPGL (P <0,02). While 15/82 (18,29%) cases with SDHB mutations do not have a malignancy potential according to PASS classification, 5/32 (15,63%) cases has (p=0,73). TAPPGL, HNPGL and Pheo sub-groups have a significant difference between SDHB expression (p <0,02), malignancy potential according to PASS classification (p <0,0001) and Ki-67 proliferation index (p <0,0001). Conclusion: To identify patients for molecular pathological examination, routine application of SDHB immunohistochemistry to PPGL tumors are suggested especially in HNPGLs.
Gul, A., Keser, S., Barisik, N., Gurbuz, Y., Sensu, S., & Erdogan, N. (2021). Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) Immunohistochemistry in Pheochromocytoma, Head and Neck Paraganglioma, Thoraco-Abdomino-Pelvic Paragangliomas: Is It a Good Idea to Use in Routine Work?. Asian Pacific Journal of Cancer Prevention, 22(6), 1721-1729. doi: 10.31557/APJCP.2021.22.6.1721
MLA
Aylin Ege Gul; Sevinc Hallac Keser; Nagehan Ozdemir Barisik; Yesim Saliha Gurbuz; Sibel Sensu; Nusret Erdogan. "Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) Immunohistochemistry in Pheochromocytoma, Head and Neck Paraganglioma, Thoraco-Abdomino-Pelvic Paragangliomas: Is It a Good Idea to Use in Routine Work?". Asian Pacific Journal of Cancer Prevention, 22, 6, 2021, 1721-1729. doi: 10.31557/APJCP.2021.22.6.1721
HARVARD
Gul, A., Keser, S., Barisik, N., Gurbuz, Y., Sensu, S., Erdogan, N. (2021). 'Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) Immunohistochemistry in Pheochromocytoma, Head and Neck Paraganglioma, Thoraco-Abdomino-Pelvic Paragangliomas: Is It a Good Idea to Use in Routine Work?', Asian Pacific Journal of Cancer Prevention, 22(6), pp. 1721-1729. doi: 10.31557/APJCP.2021.22.6.1721
VANCOUVER
Gul, A., Keser, S., Barisik, N., Gurbuz, Y., Sensu, S., Erdogan, N. Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) Immunohistochemistry in Pheochromocytoma, Head and Neck Paraganglioma, Thoraco-Abdomino-Pelvic Paragangliomas: Is It a Good Idea to Use in Routine Work?. Asian Pacific Journal of Cancer Prevention, 2021; 22(6): 1721-1729. doi: 10.31557/APJCP.2021.22.6.1721
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