Objective: Lung cancer is one of the most prevalent cancers and the leading cause of cancer-related deaths worldwide. MicroRNAs regulate more than 60% of human genes, including tumor suppressor genes and oncogenes. Accordingly, they can affect cancer risk. This study aimed to evaluate the role of serum miR-148a as a non-invasive biomarker in non-small cell lung cancer (NSCLC) patients and to assess the correlation between miR-148a and Bcl-2, as one of its target proteins. Materials and Methods: A total of 50 newly diagnosed NSCLC cases and 30 apparently healthy controls were recruited in this study. MiR-148a level was measured by TaqMan- Real time RT-PCR assay and Bcl-2 level was measured by ELISA. Results: Significant lower expression of serum miR-148a and higher serum Bcl-2 levels were observed in NSCLC patients as compared to the control group (p
Elnaggar, G. Nabil , El-Hifnawi, N. M , Ismail, A. , Yahia, M. and Elshimy, R. A A (2021). Micro RNA-148a Targets Bcl-2 in Patients with Non-Small Cell Lung Cancer. Asian Pacific Journal of Cancer Prevention, 22(6), 1949-1955. doi: 10.31557/APJCP.2021.22.6.1949
MLA
Elnaggar, G. Nabil, , El-Hifnawi, N. M, , Ismail, A. , , Yahia, M. , and Elshimy, R. A A. "Micro RNA-148a Targets Bcl-2 in Patients with Non-Small Cell Lung Cancer", Asian Pacific Journal of Cancer Prevention, 22, 6, 2021, 1949-1955. doi: 10.31557/APJCP.2021.22.6.1949
HARVARD
Elnaggar, G. Nabil, El-Hifnawi, N. M, Ismail, A., Yahia, M., Elshimy, R. A A (2021). 'Micro RNA-148a Targets Bcl-2 in Patients with Non-Small Cell Lung Cancer', Asian Pacific Journal of Cancer Prevention, 22(6), pp. 1949-1955. doi: 10.31557/APJCP.2021.22.6.1949
CHICAGO
G. Nabil Elnaggar , N. M El-Hifnawi , A. Ismail , M. Yahia and R. A A Elshimy, "Micro RNA-148a Targets Bcl-2 in Patients with Non-Small Cell Lung Cancer," Asian Pacific Journal of Cancer Prevention, 22 6 (2021): 1949-1955, doi: 10.31557/APJCP.2021.22.6.1949
VANCOUVER
Elnaggar, G. Nabil, El-Hifnawi, N. M, Ismail, A., Yahia, M., Elshimy, R. A A Micro RNA-148a Targets Bcl-2 in Patients with Non-Small Cell Lung Cancer. Asian Pacific Journal of Cancer Prevention, 2021; 22(6): 1949-1955. doi: 10.31557/APJCP.2021.22.6.1949
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