Overexpression of c-Met is Associated with Poor Prognosis in Glioblastoma Multiforme: A Systematic Review and Meta-Analyses

Document Type : Systematic Review and Meta-analysis


1 Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

2 Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

3 Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

4 Department of Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

5 Department of Radiology, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.


Objective: The aim of this study is to evaluate the association of c-Met overexpression with survival of glioblastoma multiforme (GBM) patients. Methods: A systematic review with meta-analyses was conducted on related articles from PubMed, EBSCOhost, Scopus, and Cochrane databases with last updated search on October 31, 2020. A total of 7 studies regarding c-Met overexpression and overall survival (OS) and/or progression free survival (PFS) are included in this study. Results: All studies used immunohistochemistry to examine the expression of c-Met protein. The results showed that the positive rate of c-Met overexpression was detected in approximately 33,9% - 60,5% of GBM patients. c-Met overexpression was related to worse OS (HR: 1,74; 95% CI: 1,482-2,043; Z=6,756; p<0,001) and PFS (HR: 1,66; 95% CI: 1,327-2,066; Z=4,464; p<0,001) in GBM patients. Low heterogeneity of subjects was found in both OS and PFS analyses, I2 values were 7,8% and 0,0%, respectively. Conclusion: In conclusion, c-Met overexpression is significantly related to shorter OS and PFS in GBM patients, so c-Met can be considered as a potential prognostic indicator in GBM.


Main Subjects