Assessment of the Risk of Breast Cancer Development Applying NCI Tool among Iraqi Women

Al Talebi, Zainab Abbas; Ali, Seenaa Kadhum; Kareem, Zinah Kadhim; Al-Koofee, Dhafer A.F

doi:10.31557/APJCP.2021.22.10.3121

Assessment of the Risk of Breast Cancer Development Applying NCI Tool among Iraqi Women

Document Type : Research Articles

Authors

¹ College of Science, University of Babylon, Iraq.

² Deptment of Chemistry, Faculty of Education for Girls, University of Kufa, Iraq.

³ Manager of AL Mustensrya Family Center, Iraq.

⁴ Deptment of Clinical Laboratory Science, Faculty of Pharmacy, University of Kufa, Iraq.

10.31557/APJCP.2021.22.10.3121

Abstract

Objective: As part of the bioinformatics studies, we utilized National Cancer Institute (NCI)’s Breast Cancer Risk Assessment Tool to estimate the five-year period and lifetime risk of breast cancer development among Iraqi risky women. Methods: Totally, 110 risky women aged 21-67 (mean=36±7.4) years were interviewed by a series of questions regarding the risk of breast cancer development. Moreover, 100 cases with mutation in the BRCA1 or BRCA2 genes were included. Results: Our results demonstrated that the patient’s estimated risk of breast cancer development during the next five years and lifetime (until the age 90 years) included 0.96% (p=0.211) and 9.97% (p=0.002), respectively being relatively low. Accordingly, the lifetime risk for the breast cancer development was significantly higher (10.38%) than that of 5-year. However, the age of patients was not significantly associated to the breast cancer development as there was no significant difference among various age groups. Conclusion: It was concluded that long-term or lifetime period plays as a significant risk factor for developing breast cancer among female patients who had had a screening episode in Iraq.

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