The Effect of Gene Mutations on Metastasis and Overall Survival in Metastatic and Nonmetastatic Colon Cancers

Document Type : Research Articles


1 Uskudar University, Medical Faculty, Medical Genetics Department, Umraniye, 34768 Istanbul, Turkey.

2 Université de Strasbourg, Service de chirurgie vasculaire et de transplantation, Nouvel Hôpital Civil, Université de Strasbourg 1 Place de l’Hôpital 67000 Strasbourg, France.

3 Erciyes University , Medical Faculty, Medical Genetics Department, 38280, Kayseri, Turkey.

4 Yozgat City Hospital,66100, Yozgat, Turkey.

5 Betul- Ziya Eren Genome and Stem Cell Center, 38280, Kayseri, Turkey.

6 Erciyes University, Medical Faculty, Pathology Department, 38280, Kayseri, Turkey.

7 Erciyes University, Medical Faculty, Oncology Department,38280, Kayseri, Turkey.


Objective: It is known that many genes are associated with colon cancer. We aimed to investigate the effect of gene mutations on metastasis and overall survival in metastatic and non metastatic colon cancers. Methods: A total of 50 patients with metastatic (n=25) and non metastatic (n=25) diagnosed with colon cancer between 2010 and 2018 were included in the study. APC, MUTYH, RAD50, MEN1, ATM, PALB2, NSH2, BRCA1, BRCA2, MLH1, BRIP1, TP53, PTEN, BARD1, MSH6, PMS2, NBN, and FAM175A gene mutations were evaluated using the next generation sequencing method. The effect of gene mutations on metastasis and overall survival were evaluated. Results: The mean age of patients with colon cancer without distant metastasis was 48.64±14.72 years and for patients with distance metases was 56.68±11.65. The mean survival time of colon cancer patients with distant organ metastasis after the metastasis date was 104.36±58.59 weeks. The presence of APC, MUTYH, and TP53 genetic mutations was observed with a higher rate in metastatic colon cancer (p<0.05). Conclusion: We showed that APC, MUTYH, and TP53 mutations are associated with distant organ metastasis. 


Main Subjects

Volume 22, Issue 12
December 2021
Pages 3839-3846
  • Receive Date: 05 April 2021
  • Revise Date: 03 October 2021
  • Accept Date: 20 December 2021
  • First Publish Date: 20 December 2021