Clinical Significance of MAP-7 and FOXC1 in Egyptian Acute Myeloid Leukemia Patients

Document Type : Research Articles

Authors

1 Department of Clinical Pathology, National Cancer Institute Cairo University, Cairo, Egypt.

2 Department of Medical Oncology, National Cancer Institute Cairo University, Cairo, Egypt.

Abstract

Purpose: The present study aimed to report the clinical correlations and prognostic significance of microtubule-associated protein-1 (MAP-7) and forkhead box transcription factor-C1 (FOXC1) expression in Egyptian patients with newly diagnosed acute myeloid leukemia (AML). Methods: The study included 80 adults with newly diagnosed AML. Laboratory investigations included complete blood count, morphological examination of bone marrow aspirate, immunophenotyping, conventional karyotyping and molecular study for fms-like tyrosine kinase 3 (FLT3), nucleophosmin-1 (NPM1) and CCAAT/enhancer binding protein α (CEBPA) mutations. MAP-7 and FOXC1 expressions in bone marrow were determined using RT-PCR. Patients were followed for a median (range) period of 6.4 (1.0-35) months. The study outcomes included treatment response, progression-free survival (PFS) and overall survival (OS). Results: Patients with low FOXC1 expression had significantly lower mortality rate (60.0 % versus 84.6 %, p=0.021), significantly longer PFS duration and significantly longer OS. No significant differences were noted between MAP7 expression groups regarding treatment response, mortality rate, PFS duration and OS duration. Interestingly, a significant direct correlation was noted between FOXC1 and MAP7 expressions (r=0.25, p=0.027). Conclusions: FOXC1 and MAP7 expressions are significantly correlated. High expression of FOXC1 in Egyptian population may be related to shorter OS and PFS.

Keywords

Asian Pacific Journal of Cancer Prevention
Volume 23, Issue 5
May 2022
Pages 1619-1626

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History

  • Receive Date: 06 October 2021
  • Revise Date: 19 March 2022
  • Accept Date: 14 May 2022

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