Association of Physical Activity and Sedentary Behavior with Colorectal Cancer Risk in Moroccan Adults: A Large-Scale, Population-Based Case–Control Study

Hatime, Zineb; El Kinany, Khaoula; Huybrechts, Inge; Murphy, Neil; Gunter, Marc J; Khalis, Mohamed; Meimouna, Sidi Deoula; Boudouaya, Hanae Abir; Benslimane, Abdelilah; EL ASRI, Achraf; Abkari, Mohammed; Bendahhou, Karima; Ismaili, Moulay Zahi; El Rhazi, Karima

doi:10.31557/APJCP.2022.23.6.1859

Association of Physical Activity and Sedentary Behavior with Colorectal Cancer Risk in Moroccan Adults: A Large-Scale, Population-Based Case–Control Study

Document Type : Research Articles

Authors

¹ Department of Epidemiology and Public Health, Faculty of Medicine and pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco.

² Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization, Lyon, France.

³ School of Public Health, Mohammed VI University of Health Sciences, Casablanca, Morocco.

⁴ Department of Gastroenterology, Fez, Morocco.

⁵ Department of Medical Oncology, Casablanca, Morocco.

⁶ Department of Gastroenterology, Oujda, Morocco.

10.31557/APJCP.2022.23.6.1859

Abstract

Background: Physical activity has been associated with a lower risk of colorectal cancer in studies mainly conducted in high-income countries, while sedentary behavior has been suggested to increase CRC risk. In this study, we aimed to investigate the role of physical activity and sedentary behavior on CRC risk in the Moroccan population. Methods: A case-control study was conducted involving 1516 case-control pairs, matched on age, sex and center in five university hospital centers. A structured questionnaire was used to collect information on socio-demographics, lifestyle habits, family history of CRC, and non-steroidal anti-inflammatory drug (NSAID) use. Information on physical activity and sedentary behavior were collected by the Global Physical Activity Questionnaire (GPAQ). For each activity (work, household, and recreational activities), a metabolic equivalent (MET) was calculated using GPAQ recommendations. Conditional logistic regression models were used to assess the association between physical activity, sedentary behavior and the risk of overall CRC, colon cancer, and rectal cancer taking into account other CRC risk factors. Results: High level of physical activity was associated with lower risk of rectal cancer, colon cancer, and overall CRC, the adjusted odds ratios (ORa) for the highest versus the lowest level of activity were 0.67 (95% CI: 0.54-0.82), 0.77 (95% CI: 0.62-0.96), and 0.72 (95% CI: 0.62-0.83), respectively. In contrast, sedentary behavior was positively associated with rectal cancer risk (ORa=1.19, 95% CI: 1.01-1.40), but was unrelated to colon cancer risk (ORa=1.02, 95% CI: 0.87-1.20). Conclusion: We found an inverse association between physical activity and CRC risk in the Moroccan population, and a positive association between sedentary behavior and rectal cancer risk. Considering that one-third of the total population studied had a sedentary lifestyle, these results may be used to improve strategies of public health suitable for Moroccan population.

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