A New Complex Design of Fe (II) Isoleucine Dithiocarbamate as a Novel Anticancer and Antivirus against SARSCOV-2 (COVID-19)

Irfandi, Rizal; Riswandi, Riswandi; Raya, Indah; Ahmad, Ahyar; Fudholi, Ahmad; Jarre, Sulistiani; Tirto Sari, Dewi Ratih; Santi, Santi; Wijaya, Ronald Ivan; Prihantono, Prihantono

doi:10.31557/APJCP.2022.23.9.3113

A New Complex Design of Fe (II) Isoleucine Dithiocarbamate as a Novel Anticancer and Antivirus against SARSCOV-2 (COVID-19)

Document Type : Research Articles

Authors

¹ Doctoral Program, Department of Chemistry, Faculty of Mathematics, and Natural Science, Hasanuddin University Makassar, Indonesia.

² Department of Biology Education, Faculty of Teacher Training and Education, Universitas Puangrimaggalatung, Sengkang, Indonesia.

³ Department of Chemistry, Faculty of Mathematics, and Natural Science, Hasanuddin University Makassar, Indonesia.

⁴ Solar Energy Research Institute, Universiti Kebangsaan Malaysia 43600 UKM Bangi, Selangor, Malaysia.

⁵ Research Centre for Electrical Power and Mechatronics, Institute of Science (LIPI), Bandung, Indonesia.

⁶ Department of Pharmacy, Faculty of Medical Science, Universitas Ibrahimy, Situbondo, East Java, Indonesia.

⁷ Medical Laboratory Technology, Faculty of Health Technology, Megarezky University, Makassar, Indonesia.

⁸ Department of Surgery, Faculty of Medical, Hasanuddin University, Makassar, Indonesia.

10.31557/APJCP.2022.23.9.3113

Abstract

Background: This study was carried out to synthesize a new complex of Fe(II) with isoleucine dithiocarbamate ligand and to determine its potential as an anticancer and antiviral agent for SARSCOV-2. Methods: The synthesized complexes were then characterized by UV-vis and FT-IR spectroscopy and their melting points. The value of the conductivity of the complex compound is also determined. Anti-cancer activity was tested in vitro and molecular docking. Its potential as an antiviral against SARSCOV-2 was also carried out by molecular docking. Pharmacokinetics/ADMET properties were also carried out on the complex. Result: Spectral results showed the successful synthesis of Fe(II) isoleucine dithiocarbamate complex. The complex produced UV-vis spectra at 268 and 575 nm, and the IR data at 399–599 cm-1 showed the coordination between the Fe(II) atoms with sulphur, nitrogen and oxygen of the isoleucine dithiocarbamate ligand. Fe(II) isoleucine dithiocarbamate had a cytotoxicity effect on the MCF-7 cell line (IC50 =613 µg/mL). The complex significantly caused morphological changes in the breast cancer cell line, finally leading to cell apoptosis. Conclusion: Cytotoxic test of Fe(II) isoleucine dithiocarbamate showed moderate anticancer activity on MCF-7 cancer cells and showed antiviral activity against SARSCOV-2 by interfering with spike glycoprotein –ACE2 receptors, and inhibiting major proteases and 3Clpro.

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