MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression

Document Type : Research Articles

Authors

1 Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Egypt.

2 Department, of Pathology, Faculty of Medicine, Zagazig University, Egypt.

3 Gynecology and Obstetrics department, Faculty of Medicine, Zagazig University, Egypt.

4 Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Egypt.

Abstract

Objective: To asses miR-379-5p expression in endometrial cancer (EC) and its correlation with ROR1 expression and to investigate the relation between miR-379-5p and ROR1 expressions and the clinicopathological picture of EC. Methods: Fifty female of EC were joined to this study. The gene expression of miR-379-5p (by quantitative real time-PCR) and ROR1 (by quantitative real time-PCR and immunohistochemistry) were studied in EC and normal nearby endometrial tissue. Results: The gene expression of miR-379-5p was significantly downregulated while that of ROR1 was significantly upregulated in EC tissues compared to adjacent normal endometrial tissues. Furthermore, miR-379 and ROR1 expressions significantly associated with tumor stage (P< 0.045), grade (P< 0.001), myometrial invasion (P <0.001) and LN metastasis (P< 0.034). In addition, miR-3795p and ROR1 gene expression were negatively correlated (r = -0.746, P < 0.001). Conclusions: In EC, miR-379-5p can be used as a diagnostic marker, and ROR1 could be a potential target of miR-379-5p.

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Asian Pacific Journal of Cancer Prevention
Volume 24, Issue 1
January 2023
Pages 239-248

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History

  • Receive Date: 01 August 2022
  • Revise Date: 24 October 2022
  • Accept Date: 13 January 2023

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