Profiling the Expression and Prognostic Values of FYN, A Non-Receptor Tyrosine Kinase, in Different Histological Types of Epithelial Ovarian Cancer

Document Type : Research Articles

Authors

1 Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

2 Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Abstract

Objective: This study was aimed at evaluating FYN expression among different histologic types of epithelial ovarian cancer (EOC) and its associated prognostics. Methods: The FYN expression levels using quantitative real-time PCR method were evaluated in 98 primary EOC. Receiver operating characteristic curve were used to select an optimal cut-off value for determining the presence or absence of a disease progression. Result: The median level of FYN expression varied among different EOC types, being the highest in high-grade serous carcinomas and the lowest in clear cell carcinomas (CCC). Using the cutoff FYN value to predict disease progression, the FYN-positive group had a poorer progression-free survival (PFS) compared to the FYN-negative group (p = 0.001). In multivariate Cox regression analysis, FYN expression was an independent predictor for disease progression (Hazard ratio = 2.30; 95% CI: 1.21- 4.38; p = 0.011). In subgroup analysis, FYN expression was significantly associated with lower PFS in early stage CCC patients (p = 0.009). Conclusion: FYN expression is variable among different types of EOC while impacting on the prognostic values in patients with early stage CCC.

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Asian Pacific Journal of Cancer Prevention
Volume 24, Issue 1
January 2023
Pages 321-329

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History

  • Receive Date: 02 September 2022
  • Revise Date: 30 October 2022
  • Accept Date: 20 January 2023

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