Prevalence and Distribution of High- and Low- Risk HPV Genotypes in Women Living in the Metropolitan Area of Naples: A Recent Update

Document Type : Research Articles


1 Section of Microbiology and Virology, University Hospital “Luigi Vanvitelli”, 80138 Naples, Italy.

2 Experimental Zooprophylactic Institute of Southern, Italy.

3 Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy.

4 Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.

5 Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi.

6 Department of Health Hygiene and Evaluation Medicine UOC. Clinical and Microbiological Pathology, University Hospital S. Giovanni di Dio e Ruggi D’Aragona, Salerno Medical School, Città di Ippocrate, 84131 Salerno, Italy.


Introduction: Human papillomavirus (HPV) can infect both male and female genitals, skin, and mucous membranes, causing benign or malignant lesions. HPV is a common sexually transmitted infection and it is the main cause of cervical cancer. The present retrospective study updated the previously published data on HPV genotypes distribution among women living in Naples. Materials and methods: In this study, 502 cervical scrape specimens were collected from women with abnormal cytological indication and analyzed for HPV DNA identification by Linear Array HPV genotyping test. Results: The HPV infection rate was 24.1%. HPV-16 (14.6%) was the most representative HR-HPV genotypes, followed by HPV-31 (13.8%), -18 (9.2%), and HPV-51 (8.5%). In addition, HPV-42 (16.4%) was the most prevalent genotype among LR-HPV  genotypes (low-risk human papillomavirus). It was also found that women at the age group of 23-29 years (42.5%) were at the highest risk of HPV infection. It was found that the HPV-16 frequency decreased, but HPV-31 and -18 frequency increased a little. The LR HPV-53 frequency decreased, leaving the first place for abundance to the LR HPV-42. HPV-6 frequency did not change. LR HPV -11 was no more present. Merging <23 and 23-29 age classes into one class followed the same result. Conclusion: HPV prevalence declined in comparison to the previous data. A frequency variation was recorded for several genotypes in this study.  Data can be useful to implement the preventative strategies and to promote HPV vaccination.


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