Document Type : Systematic Review and Meta-analysis
Authors
1
Student Research Committee, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.
2
Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
3
Department of Nutrition, School of Public Health, International Campus, Iran University of Medical Sciences, Tehran, Iran.
4
Departments of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5
Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
6
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
7
Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan, Iran.
8
Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
9
Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
10
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
11
Reproductive Health Research Center, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Abstract
Background: Radiation dermatitis (RD) is a common side effect of radiotherapy in most breast cancer patients. Curcumin has recently attracted more attention for managing the side effects of breast cancer treatments. This review study aimed to investigate the effect of curcumin on the severity of radiation dermatitis in patients with breast cancer. Methods: All eligible randomized controlled trials (RCTs) were collected by searching PubMed, Scopus, Cochrane, and Web of Science. The effect size was expressed as weighted mean difference (WMD) and 95% confidence interval (CI). Study heterogeneity was assessed through Q statistics and I-squared. Results: Four RCTs with 882 patients were included in the final analysis. The results of the meta-analysis indicated that curcumin supplementation significantly reduced radiation dermatitis severity (RDS) score in the intervention group compared to the control group (WMD=-0.50; 95% CI -0.72 to -0.27, P <0.001). A significant heterogeneity was observed between the studies (I2 = 95.7%, P < 0.001). Conclusion: Based on the results of the present study, curcumin has significant effects in reducing the severity of radiation dermatitis in breast cancer patients receiving radiotherapy. Further well-designed longitudinal studies are recommended to confirm these results and to discover the underlying mechanisms of the effects of curcumin on the severity of radiation dermatitis in patients with cancer.
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