Document Type : Systematic Review and Meta-analysis
Department of Pharmacy Technology, Higher Institute of Medical Sciences and Technology, Bani Waleed, Libya.
Department of Pharmacy, Al Rafidain University College, Baghdad, Iraq.
Department of Clinical Pharmacy, Faculty of Pharmacy, Universiti Teknologi MARA Selangor Branch, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
Cardiology Therapeutics Research Group, Faculty of Pharmacy, Universiti Teknologi MARA Selangor Branch, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
School of Pharmacy, Monash University Malaysia, Selangor, Malaysia.
Discipline of Clinical Pharmacy, University of Science and Technology, Sanaa, Yemen.
Background: Fatigue is a typical consequence of cancer that can affect one’s quality of life (QOL). The goal of this review is to provide comprehensive data on the impact of fatigue on QOL of cancer patients. Methods: An electronic data search in Web of Science, SCOPUS, and PubMed for relevant papers; those written in English; those reporting quantitative data; and those including more than one hundred patients who received just chemotherapy were included. Studies involving participants that received other kinds of anti-neoplastic therapies were excluded. Results: A total of 35 papers published between January 2000 and December 2021 were retrieved from the search databases of which (11612 patients) met the inclusion criteria. Findings showed that fatigue negatively affected QOL with a pooled prevalence of 49% (95% CI; 25.00-74.00) and the significant heterogeneity between articles was (I²=98%, P <0.001). Further, breast cancer contributed to the majority of selected articles with about 55 % (95%CI; 9:00- 94:00), followed by cancer (unspecified) 44% (95%CI; 5:00 – 92:00). Most studies (71%) (95%CI; 4:00 – 99:00) used the brief fatigue inventory (BFI) tool to assess severity of fatigue and 39% (95%CI; 17:00 -68:00) employed the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire to evaluate QOL among cancer survivors. Conclusion: The prevalence of fatigue in cancer patients is high and fatigue has a negative impact on QOL of cancer patients receiving chemotherapy. Directionality, fatigue needs to be addressed and treated properly for better improvement of health status and QOL in cancer patients.