Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia.
Objective: Our study aimed to characterize alteration in the immunohistochemical expression of estrogen, progesterone and androgen receptor in the tumour cells of primary pleomorphic adenomas and recurrent pleomorphic adenomas. Methods: A retrospective study of data including 30 cases of primary pleomorphic adenomas (PA) without recurrences and 15 cases of recurrent pleomorphic adenomas were examined (RPA). RPA included 8 males and 7 females. Immunohistochemical expression of estrogen, progesterone and androgen receptor was examined in the selected cases. The percentage of slides was semi-quantitatively assessed by two independent observers and scores were given. The statistical analysis included the use of descriptive statistics and proportional frequencies. Results: AR expression was identified in 12 (40. %) out of 30 cases of (PA) pleomorphic adenomas and 7 of 15 cases recurrent pleomorphic adenomas (RPA) (46 %). The results showed that ER and PR expression were negative in PA and RPA. Conclusion: Androgen receptors might have role in pathogenesis of PA and RPA. Estrogen and progesterone receptors have no role in development of recurrent pleomorphic salivary adenoma.
Tarakji, B., & Mehsen Alali, F. (2023). Estrogen, Progesterone and Androgen Receptor in Primary and Recurrent Pleomorphic Salivary Adenomas. Asian Pacific Journal of Cancer Prevention, 24(5), 1731-1735. doi: 10.31557/APJCP.2023.24.5.1731
MLA
Bassel Tarakji; Faisal Mehsen Alali. "Estrogen, Progesterone and Androgen Receptor in Primary and Recurrent Pleomorphic Salivary Adenomas". Asian Pacific Journal of Cancer Prevention, 24, 5, 2023, 1731-1735. doi: 10.31557/APJCP.2023.24.5.1731
HARVARD
Tarakji, B., Mehsen Alali, F. (2023). 'Estrogen, Progesterone and Androgen Receptor in Primary and Recurrent Pleomorphic Salivary Adenomas', Asian Pacific Journal of Cancer Prevention, 24(5), pp. 1731-1735. doi: 10.31557/APJCP.2023.24.5.1731
VANCOUVER
Tarakji, B., Mehsen Alali, F. Estrogen, Progesterone and Androgen Receptor in Primary and Recurrent Pleomorphic Salivary Adenomas. Asian Pacific Journal of Cancer Prevention, 2023; 24(5): 1731-1735. doi: 10.31557/APJCP.2023.24.5.1731
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