Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia

Document Type : Research Articles


1 Hematology Unit, Department of Clinical Pathology, Mansoura University, Egypt.

2 Oncology Unit, Mansoura University Oncology Center, Mansoura University, Egypt.


Background: little is known regarding the prognostic value of soluble CD200 (sCD200)in  chronic lymphocytic leukemia patients. Therefore, the objective of our study is  to address the prognostic value of sCD200 antigen concentration on  CLL patients outcome. Methods: Determination of  serum sCD200 was done using ELISA kit in 158 CLL patients at diagnosis  before start of therapy beside 21 healthy controls. Results: sCD200 concentration levels was significantly higher in CLL patients as compared to healthy controls.  High sCD200 was associated with poor prognostic markers (high expression of CD38+% and ZAP70+, high LDH, high risk Rai stages, unfavorable cytogenetic finding, time to first treatment (TTT) as well as patients outcome (P<0.001 for All). sCD200 at cut-off value ( 752.5 pg/ml) could predicts TTT with specificity 83.4%. Conclusion: Determination of sCD200 concentration levels at diagnosis could be used as a prognostic biomarker in CLL patients. 


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