Objectives: To evaluate immunohistochemical expression of PD-L1 in cases of gastric adenocarcinoma. To correlate PD-L1 immuno-histochemical expression with other available clinico-pathological parameters such as age, sex, grade, stage, lymph node (L.N) metastasis and others. Material and methods: The present retrospective study retrieved the data and archived paraffin blocks of 60 cases of Gastric carcinoma. Immunohistochemical evaluation was done to assess the expressions of PD-L1 in the tumor cells (TC), tumor infiltrated lymphocytes (TILs) and combined positive score (CPS). Results: TC PD-L1 expression was detected in 56.7% of cases, TILs PD-L1 expression was detected in 53.3 % of cases and CPS PD-L1 expression was detected in 63.3% of case, with no statistically significant correlation with clinico-pathological parameters except TILs PD-L1 expression showed statistically significant correlation with positive TILs (P value ˂0.019). Conclusion: Our findings supported the expression of PD-L1 by TC, TILs, and CPS in gastric cancer, with increased expression in a subpopulation of TILs rich in PD-L1 identifying them as potential targets for PD-1/PD-L1 therapy.
Ali, S. Mohammed , Helmy, D. Omar , Abdelhamid, H. Soliman and Abdelmagid Mahmoud, M. Salah Eldin (2023). Expression of Programmed Death Ligand1 (PD-L1) in Gastric Carcinoma (Histopathological and Immunohistochemical Study). Asian Pacific Journal of Cancer Prevention, 24(7), 2295-2303. doi: 10.31557/APJCP.2023.24.7.2295
MLA
Ali, S. Mohammed, , Helmy, D. Omar, , Abdelhamid, H. Soliman, and Abdelmagid Mahmoud, M. Salah Eldin. "Expression of Programmed Death Ligand1 (PD-L1) in Gastric Carcinoma (Histopathological and Immunohistochemical Study)", Asian Pacific Journal of Cancer Prevention, 24, 7, 2023, 2295-2303. doi: 10.31557/APJCP.2023.24.7.2295
HARVARD
Ali, S. Mohammed, Helmy, D. Omar, Abdelhamid, H. Soliman, Abdelmagid Mahmoud, M. Salah Eldin (2023). 'Expression of Programmed Death Ligand1 (PD-L1) in Gastric Carcinoma (Histopathological and Immunohistochemical Study)', Asian Pacific Journal of Cancer Prevention, 24(7), pp. 2295-2303. doi: 10.31557/APJCP.2023.24.7.2295
CHICAGO
S. Mohammed Ali , D. Omar Helmy , H. Soliman Abdelhamid and M. Salah Eldin Abdelmagid Mahmoud, "Expression of Programmed Death Ligand1 (PD-L1) in Gastric Carcinoma (Histopathological and Immunohistochemical Study)," Asian Pacific Journal of Cancer Prevention, 24 7 (2023): 2295-2303, doi: 10.31557/APJCP.2023.24.7.2295
VANCOUVER
Ali, S. Mohammed, Helmy, D. Omar, Abdelhamid, H. Soliman, Abdelmagid Mahmoud, M. Salah Eldin Expression of Programmed Death Ligand1 (PD-L1) in Gastric Carcinoma (Histopathological and Immunohistochemical Study). Asian Pacific Journal of Cancer Prevention, 2023; 24(7): 2295-2303. doi: 10.31557/APJCP.2023.24.7.2295
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