Agreement between Self- and Physician‑Sampling for Detection of High‑Risk Human Papillomavirus Infections in Women Attending Cervical Screening at National Cancer Institute, Thailand

Sangrajrang, Suleeporn; Pitakkarnkul, Supakorn; Muwonge, Richard; Ploysawang, Pattama; Pangmuang, Parinda; Seeda, Kanda; Basu, Partha

doi:10.31557/APJCP.2023.24.8.2615

Agreement between Self- and Physician‑Sampling for Detection of High‑Risk Human Papillomavirus Infections in Women Attending Cervical Screening at National Cancer Institute, Thailand

Document Type : Research Articles

Authors

¹ National Cancer Institute, Department of Medical Services, Ministry of Public Health, Bangkok, Thailand.

² Division of Gynecologic Oncology, National Cancer Institute, Department of Medical Services, Ministry of Public Health, Bangkok, Thailand.

³ Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer, Lyon, France.

10.31557/APJCP.2023.24.8.2615

Abstract

Background: We determined testing of self-sampling vagina swabs for Human Papilloma Virus (HPV) can be used to screen for cervical disease in outpatient clinics. Methods: In this study, women attending cervical cancer screening clinic and gynecology clinic of the National Cancer Institute were invited to take a vaginal self-sampling and physician-collected cervical sampling. Results: Of 268 participants, 20 (7.5%) were HPV-positive on the physician-collected samples. Among these screen-positive women, only two (0.7%) had HPV 18 and/or 45 and none had HPV 16 infections. For the self-collected samples, 4 participants had invalid HPV test results. Of the remaining 264 women with valid test results on self-collected samples, 29 (11.0 %) were HPV-positive, of whom, two (0.8%) were infected with HPV 16 and one (0.4%) with HPV 18 and/or 45 infections. The agreement between self-sampling and physician-sampling HPV test results (when two HPV results categories were considered) was 92. 8% with a moderate Kappa value of 0.57. Conclusion: Overall, self-sampling seems to be a reliable alternative to health-provider collection. However, instructions on proper procedures for sample collection to the women are important step before general roll out.

Keywords