Objective: This study aimed to assess whether pretreatment tumor tissue microvessel density (MVD) could be a potential predictive marker for Mandard response in LARC treated with nCRT. Methods: A retrospective analysis was performed in pretreatment paraffin-embedded specimens of 31 pathologically confirmed rectal adenocarcinoma. All patients received nCRT and subsequent total mesorectal resection. Tumor MVD was determined by an average number of counted CD34-stained endothelial cells from two selected fields at 200x magnification in each slide and categorized into two groups: low MVD (</=60) and high MVD (> 60). The tumor response was determined using the Mandard tumor regression grading system. The subjects were grouped according to their TRG into responder (TRG 1-3) and non-responder (TRG 4–5). Result: Twenty out of thirty-one patients (64.5%) were defined as responders. Eleven patients (35.5%) were defined as non-responders. MVD was significantly associated with tumor responsiveness to nCRT (p < 0.05). High MVD was shown to be an independent risk factor associated with tumor resistance to nCRT (OR, 22.58; 95% CI, 1.943-262.34; p = 0.013). A strong correlation was found between MVD and TRG (correlation coefficient value of 0.642, p <0.01), between MVD and vascular invasion (correlation coefficient value of 0.618, p <0.01), and between nodal involvement and vascular invasion (correlation coefficient value of 0.521, p <0.01). A moderate correlation was found between nodal involvement and vascular invasion (correlation coefficient value of 0.406, p <0.05). Conclusion: High MVD in pretreatment tumor tissue was significantly associated with the tumor resistance to nCRT.
Boonya-Ussadorn, C., Nimmanon, T., & Anannamcharoen, S. (2023). Pretreatment Microvessel Density for Predicting of Tumor Responsiveness to Neoadjuvant Chemoradiotherapy of Locally Advanced Rectal Cancer. Asian Pacific Journal of Cancer Prevention, 24(8), 2697-2703. doi: 10.31557/APJCP.2023.24.8.2697
MLA
Chinakrit Boonya-Ussadorn; Thirayost Nimmanon; Sahaphol Anannamcharoen. "Pretreatment Microvessel Density for Predicting of Tumor Responsiveness to Neoadjuvant Chemoradiotherapy of Locally Advanced Rectal Cancer". Asian Pacific Journal of Cancer Prevention, 24, 8, 2023, 2697-2703. doi: 10.31557/APJCP.2023.24.8.2697
HARVARD
Boonya-Ussadorn, C., Nimmanon, T., Anannamcharoen, S. (2023). 'Pretreatment Microvessel Density for Predicting of Tumor Responsiveness to Neoadjuvant Chemoradiotherapy of Locally Advanced Rectal Cancer', Asian Pacific Journal of Cancer Prevention, 24(8), pp. 2697-2703. doi: 10.31557/APJCP.2023.24.8.2697
VANCOUVER
Boonya-Ussadorn, C., Nimmanon, T., Anannamcharoen, S. Pretreatment Microvessel Density for Predicting of Tumor Responsiveness to Neoadjuvant Chemoradiotherapy of Locally Advanced Rectal Cancer. Asian Pacific Journal of Cancer Prevention, 2023; 24(8): 2697-2703. doi: 10.31557/APJCP.2023.24.8.2697
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