Objectives: The present study aimed to investigate the impact of BRCA1 protein expression on the patients’ outcome of ovarian serous carcinoma, and its correlation with different clinicopathologic features. Methods: Immunohistochemistry with BRCA1 was done for 80 cases of ovarian serous carcinoma that had a positive family history. Correlation with clinico-pathologic variables and patients’ outcomes was investigated. Results: BRCA1 expression was detected in 61.2% of the studied cases. A significant relation with patients’ age, tumor grade and tumor stage was found (P<0.05). Also, there was a significant decrease in disease free survival (DFS) & overall survival (OS) in the positive BRCA1 group. Metastasis, recurrence, residual disease, and mortality rate showed significantly higher figures in patient with BRCA1 expression (P<0.05). Conclusion: Positive BRCA1 expression had proven to be associated with advanced stage & grade of tumors, as well as worsened prognostic survival parameters (metastasis, recurrence, residual disease, and mortality) in patients with ovarian serous carcinoma.
Amin, N. H , Ahmed, B. A , Abou-Bakr, A. A , Eissa, S. Sayed , Nassar, H. R , Gad, M. and Eissa, M. (2023). The Impact of BRCA1 Expression on Survival Status in Ovarian Serous Carcinoma of Egyptian Patients. Asian Pacific Journal of Cancer Prevention, 24(10), 3613-3620. doi: 10.31557/APJCP.2023.24.10.3613
MLA
Amin, N. H, , Ahmed, B. A, , Abou-Bakr, A. A, , Eissa, S. Sayed, , Nassar, H. R, , Gad, M. , and Eissa, M. . "The Impact of BRCA1 Expression on Survival Status in Ovarian Serous Carcinoma of Egyptian Patients", Asian Pacific Journal of Cancer Prevention, 24, 10, 2023, 3613-3620. doi: 10.31557/APJCP.2023.24.10.3613
HARVARD
Amin, N. H, Ahmed, B. A, Abou-Bakr, A. A, Eissa, S. Sayed, Nassar, H. R, Gad, M., Eissa, M. (2023). 'The Impact of BRCA1 Expression on Survival Status in Ovarian Serous Carcinoma of Egyptian Patients', Asian Pacific Journal of Cancer Prevention, 24(10), pp. 3613-3620. doi: 10.31557/APJCP.2023.24.10.3613
CHICAGO
N. H Amin , B. A Ahmed , A. A Abou-Bakr , S. Sayed Eissa , H. R Nassar , M. Gad and M. Eissa, "The Impact of BRCA1 Expression on Survival Status in Ovarian Serous Carcinoma of Egyptian Patients," Asian Pacific Journal of Cancer Prevention, 24 10 (2023): 3613-3620, doi: 10.31557/APJCP.2023.24.10.3613
VANCOUVER
Amin, N. H, Ahmed, B. A, Abou-Bakr, A. A, Eissa, S. Sayed, Nassar, H. R, Gad, M., Eissa, M. The Impact of BRCA1 Expression on Survival Status in Ovarian Serous Carcinoma of Egyptian Patients. Asian Pacific Journal of Cancer Prevention, 2023; 24(10): 3613-3620. doi: 10.31557/APJCP.2023.24.10.3613
)