Document Type : Research Articles
Authors
1
Department of Biology and Chemistry, Islamic Azad University of Medical Science Branch, Tehran, Iran.
2
Department of Electrical and Computer Engineering, University of Houston, Houston, TX, USA.
3
Departments of Nanotechnology, Faculty of Engineering, University of Guilan, Rasht, Iran.
4
Department of Mechanical Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran.
5
Department of Pharmaceutics, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran.
6
Dental medicine student, Pavol Jozef Šafárik University, Košice, Slovakia.
7
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.
8
Department of Life Science, College of Life Science, National Taiwan University, Taipei, Taiwan.
Abstract
Objective: Cancer poses a significant challenge in modern medicine, standing as the primary cause of death in many countries, second only to cardiovascular diseases. Among the various treatments available, carboplatin, a chemotherapy drug, is employed for specific cancer types, including brain carcinoma. The main objective of this investigation is to enhance the therapeutic efficacy of carboplatin by utilizing niosomal nanocarriers. Methods: We synthesized nanoniosomal carboplatin using the reverse-phase evaporation technique and conducted an assessment of its particle size, zeta potential, and drug-release properties. Subsequently, we evaluated the cytotoxicity of nanoniosomal carboplatin using the C6 rat glioma cell line. Results: Our research revealed that these niosomal nanoparticles possessed a particle size of 290.5±5.5 nm and a zeta potential of -21.7±7.4 mV. The amount of encapsulated drug and drug loading level were found to be 60.2±2.3% and 2.5±1.1%, respectively. Importantly, the cytotoxic impact of these nanoniosomes on the C6 rat glioma cell line exhibited a significant increase compared to the free drug (P<0.05). Conclusion: Based on our discoveries, it is evident that carboplatin niosomal nanocarriers hold potential as an innovative approach to chemotherapy for brain cancer therapy.
Keywords
Main Subjects
)