Document Type : Research Articles
Authors
1
Department of Strategic Development, Science and Education, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Astana, Republic of Kazakhstan.
2
Center for Photodynamic Therapy, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Astana, Republic of Kazakhstan.
3
Clinical and Diagnostic Department, “UMIT” International Oncological Tomotherapy Center, Astana, Republic of Kazakhstan.
4
Department of Chemotherapy, Multidisciplinary Medical Center of the Akimat of Astana, Astana, Republic of Kazakhstan.
5
Department of Radiology named after Academician Zh.Kh. Khamzabaev, Astana Medical University, Astana, Republic of Kazakhstan.
6
Department of Public Health, Astana Medical University, Astana Medical University, Astana, Republic of Kazakhstan.
Abstract
Objective: The research aim is analyzing and identify reliable genetic markers of breast cancer risk in the Kazakh population. Methods: The databases were analyzed with the selection of polymorphisms associated with the development of breast cancer and further genotypic study of a group of women with a confirmed diagnosis of breast adenocarcinoma (group No. 1) and a group of relatively healthy women (group No. 2). Result: The research presents the results of a study on the frequency of certain single-nucleotide polymorphisms in patients with breast cancer in the Republic of Kazakhstan. The frequency of single-nucleotide polymorphisms rs4646, rs1065852, rs4244285, rs67376798, rs6504950, rs2229774, rs1800056, rs16942, rs4987047 is statistically significant compared to the control group of patients. These polymorphisms in the Kazakh population have a direct association with an increased risk of breast cancer in women and may be used as cancer indicators during the genetic screening of patients with a complicated family history. Single-nucleotide polymorphisms such as rs55886062, rs3918290, rs12721655, rs4987117, rs2229774, rs11203289, rs137852576, rs11571833, rs80359062 and rs11571746 were found in more than 40. Zero percent of patients with breast cancer may be used as markers for detecting patients at increased risk of breast malignancy in the Kazakh population without a history of poor family history. Conclusion: The usage of the data obtained in a set of state programs for early screening of patients will improve the rates of early breast tumor detection, form groups of patients with a high risk of disease development and improve the quality and expectancy of life.
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