HLA-B*58 and HLA-B*27 Play a Role in the Development of Acute Leukemia: A Case Control Study

Document Type : Research Articles

Authors

1 Laboratory of Developmental Biology and Differentiation, BP 1510 El M’Naouer, Oran 1 Ahmed Ben Bella University, 31000, Oran, Algeria.

2 Hospital and University Establishment November 1, 1954, Department of Hematology and Cellular Therapy, BP 4166 Ibn Rochd, University of Oran 1, Ahmed Ben Bella, Faculty of Medicine, 31000 Oran, Algeria.

3 Hospital and University Establishment November 1, 1954, Immunology Department, 31000 Oran, Algeria.

4 Hospital and University Establishment November 1, 1954, Hemobiology Blood Transfusion Service, Blood Bank. Sincerely, 31000 Oran, Algeria.

Abstract

Background: Acute leukemia (AL) constitutes a group of malignant hematological diseases with multifactor origins. Some human leukocyte alleles (HLA) may be important genetic risk factors for development of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). It is still unknown whether there is a relationship between ALL and AML with some alleles of the major histocompatibility complex. Our study looks specifically at western and southwest Algerian populations. Method: Using the polymerase chain reaction with the sequence specific probe (PCR- SSP) method, we investigated the relationship of HLA-B alleles in 163 Algerian AL patients and 293 controls from the same ethnic origin. The study ran from 2013 – 2020. Results: Allele frequencies of HLA-B*27 and HLA-B*58 was higher in AL patients compared with control individuals; p=0.05 and p=0.03 respectively. Interestingly, all patients carrying HLA-B*27 allele and 88% of patients carrying HLA-B*58 allele had AML. However, there were no significant differences when we compared these results with the rest of AL group (HLA-B*X allele) (p=0.387). Response to induction chemotherapy treatment were comparable between the two patient groups 67% and 65% (p=0.978) respectively. Conclusion: These results suggest that the HLA-B*27 and HLA-B*58, may be factors predisposing individuals to acute leukemia, in west and southwest Algerian patients. A large-scale study is still needed to confirm these findings.

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Volume 25, Issue 1
January 2024
Pages 169-173
  • Receive Date: 12 August 2023
  • Revise Date: 25 November 2023
  • Accept Date: 22 January 2024
  • First Publish Date: 22 January 2024