Objective: We retrospectively analyzed the efficacy, focusing on overall survival (OS) and the patterns of failure, along with the toxicities of adjuvant radiotherapy (RT) in endometrial cancer patients. Methods: Two-hundred and nineteen patients with endometrial cancer patients who received adjuvant radiotherapy ± adjuvant chemotherapy (ACT) from January 2014 to December 2018 were investigated for overall survival (OS), local recurrence-free survival rate (LRFS), regional recurrence-free survival rate (RRFS), and distant metastasis-free survival rate (DMFS). Result: Two-hundred and fourteen patients were evaluated. The numbers of VBT alone, EBRT plus VBT, and adjuvant chemotherapy (ACT) plus EBRT plus VBT were 65 (30.4%), 80 (37.4%), and 69 (32.2%) patients, respectively. Stage I (107 patients) was the most common followed by stage III (87 patients). With a median follow-up time of 67 months (IQR 56–78), the 5-year overall survival rates for VBT alone, EBRT plus VBT, and EBRT plus VBT plus ACT were 84.4%, 65%, and 57.4%, respectively. The most common severe (grade 3-4) acute toxicity was neutropenia (4.6%), followed by diarrhea (3.7%). Grade 3–4 late proctitis was found in only 1.9%. On multivariate analysis, advanced age (HR 6.15, p: 0.015), lymph node involvement (HR 6.66, p: 0.039), cervical involvement (HR 10.60, p: 0.029), and substantial LVSI (HR 21.46, p: 0.005) were associated with a higher risk of death. Conclusion: Advanced age (>65), substantial LVSI, lymph node involvement, and cervical stromal involvement were associated with poor overall survival. These findings here will help identifying high-risk patients and would make it possible to avoid unnecessary adjuvant treatment among patients with a good prognosis.
Chitapanarux, N., Tharavichitkul, E., kittidachanan, K., Muangwong, P., Chakrabandhu, S., Klunklin, P., Onchan, W., Jia-Mahasap, B., Torapichattrakul, P., & Chitapanarux, I. (2024). Retrospective Analysis of All Types of Adjuvant Radiotherapy in Endometrial Cancer: Single-Center Experiences in a Middle-Income Country. Asian Pacific Journal of Cancer Prevention, 25(2), 485-494. doi: 10.31557/APJCP.2024.25.2.485
MLA
Nadee Chitapanarux; Ekkasit Tharavichitkul; Kittikun kittidachanan; Pooriwat Muangwong; Somvilai Chakrabandhu; Pitchayaponne Klunklin; Wimrak Onchan; Bongkot Jia-Mahasap; Piyapasara Torapichattrakul; Imjai Chitapanarux. "Retrospective Analysis of All Types of Adjuvant Radiotherapy in Endometrial Cancer: Single-Center Experiences in a Middle-Income Country". Asian Pacific Journal of Cancer Prevention, 25, 2, 2024, 485-494. doi: 10.31557/APJCP.2024.25.2.485
HARVARD
Chitapanarux, N., Tharavichitkul, E., kittidachanan, K., Muangwong, P., Chakrabandhu, S., Klunklin, P., Onchan, W., Jia-Mahasap, B., Torapichattrakul, P., Chitapanarux, I. (2024). 'Retrospective Analysis of All Types of Adjuvant Radiotherapy in Endometrial Cancer: Single-Center Experiences in a Middle-Income Country', Asian Pacific Journal of Cancer Prevention, 25(2), pp. 485-494. doi: 10.31557/APJCP.2024.25.2.485
VANCOUVER
Chitapanarux, N., Tharavichitkul, E., kittidachanan, K., Muangwong, P., Chakrabandhu, S., Klunklin, P., Onchan, W., Jia-Mahasap, B., Torapichattrakul, P., Chitapanarux, I. Retrospective Analysis of All Types of Adjuvant Radiotherapy in Endometrial Cancer: Single-Center Experiences in a Middle-Income Country. Asian Pacific Journal of Cancer Prevention, 2024; 25(2): 485-494. doi: 10.31557/APJCP.2024.25.2.485
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