High Expression of PXMP4 in Hepatocellular Carcinoma Tissues

Document Type : Research Articles

Authors

Faculty of Medicine, Lincoln University College, Malaysia.

Abstract

Objective: To analyze the high expression of peroxisome membrane protein 4 (PXMP4) in hepatocellular carcinoma (HCC) and its clinical significance. Methods:The expression of PXMP4 mRNA in HCC tissues and corresponding adjacent tissues was detected by Q-PCR, and the expression of PXMP4 protein was detected by Western blot and immunohistochemistry. The correlation of PXMP4 protein expression with clinicopathological features and prognosis of HCC was analyzed. Results: The expression levels of PXMP4 mRNA and protein in HCC tissues were significantly higher than those in adjacent tissues (P < 0.05), and its high expression was significantly correlated with tumor differentiation, lymph node metastasis, depth of invasion and TNM stage (P < 0.05). Patients with high expression of PXMP4 had a poor prognosis (P < 0.05). Conclusion: The high expression of PXMP4 may promote the occurrence and development of HCC, and inhibition of PXMP4 may be one of the potential molecular targets for targeted therapy of HCC.

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Asian Pacific Journal of Cancer Prevention
Volume 25, Issue 2
February 2024
Pages 603-608

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History

  • Receive Date: 03 October 2023
  • Revise Date: 18 December 2023
  • Accept Date: 16 February 2024

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