Background: In Egypt, bladder cancer occupies the second rankamong reported cancers in men. Claudins are tight junctions that have a critical role in tumor pathogenesis, invasion, progression, and metastasis and currentlyare a focus of interest for targeting therapies. Objectives: We aimed to evaluatethe immunohistochemical expression of Claudin-1 and Claudin-4 in urinary bladder urothelial carcinoma and investigate the relationshipbetweenthe expressed Claudins with differentclinicopathological parameters. Methods: Claudin-1 and Claudin-4 immunohistochemical expression was studied in 62 cases of urinary bladder urothelial carcinomas. The cases were classified into two categories; low and high Claudin-1 and Claudin-4 expression. Results: High Claudin-1 expression was detected in67.7% of the studied urothelial carcinomas while 32.3% showed low expression. Claudin-1 expression was reduced significantly with high tumor grade, non-papillary tumors, muscle invasion, schistosomal infestation, and perineural invasion (p-value < 0.05). Claudin-4 high expression was detected in 82.3% of our cases while low expression was detected in 17.7%. Claudin-4 reduced expression was significantly associated with non-papillary tumors, muscle invasion, advanced T stages, and associated lympho-vascular emboli (P-value < 0.05). Conclusion: According to the results ofthe present study, the reduced expressions of Claudin-1 and Claudin-4 provide clues concerning the progression of urothelial carcinoma. Consequently, it is thought that Claudin-1 and Claudin-4 could help to differentiatelow-grade from high-grade and muscle-invasive from non-muscle-invasive urothelial carcinomas. In addition, it can be introduced as a possible therapeutic target.
Elsayed, A., Mahmoud, E., Salem, M., & Khairy, R. (2024). Immunohistochemical Expression of Claudin-1 and Claudin-4 in Urothelial Carcinoma of the Urinary Bladder. Asian Pacific Journal of Cancer Prevention, 25(2), 637-646. doi: 10.31557/APJCP.2024.25.2.637
MLA
Aya Magdy Elsayed; Eman Ibrahim Mahmoud; Mostafa Mohamed Salem; Rasha Ahmed Khairy. "Immunohistochemical Expression of Claudin-1 and Claudin-4 in Urothelial Carcinoma of the Urinary Bladder". Asian Pacific Journal of Cancer Prevention, 25, 2, 2024, 637-646. doi: 10.31557/APJCP.2024.25.2.637
HARVARD
Elsayed, A., Mahmoud, E., Salem, M., Khairy, R. (2024). 'Immunohistochemical Expression of Claudin-1 and Claudin-4 in Urothelial Carcinoma of the Urinary Bladder', Asian Pacific Journal of Cancer Prevention, 25(2), pp. 637-646. doi: 10.31557/APJCP.2024.25.2.637
VANCOUVER
Elsayed, A., Mahmoud, E., Salem, M., Khairy, R. Immunohistochemical Expression of Claudin-1 and Claudin-4 in Urothelial Carcinoma of the Urinary Bladder. Asian Pacific Journal of Cancer Prevention, 2024; 25(2): 637-646. doi: 10.31557/APJCP.2024.25.2.637
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