Association of the CXCL12 rs1801157 Polymorphism with Breast Cancer Risk: A Meta-Analysis

Document Type : Systematic Review and Meta-analysis

Authors

1 Department of General Surgery, Babol University of Medical Sciences, Babol, Iran.

2 Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Department of Surgery, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

4 Department of Surgery, School of Medicine, Shohadaye Haft-e-Tir Hospital, Iran University of Medical Sciences, Tehran, Iran.

5 Department of Surgery, Aja University of Medical Sciences, Tehran, Iran.

6 Department of Gynecologic Oncology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

7 Preventative Gynecology Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

8 Department of Radiation Oncology, Firoozgar Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

9 Shahid Akbarabadi Cilinical Research Development Unit, Iran University of Medical Sciences, Tehran, Iran.

10 Department of Cancer Biology, College of Medicine, University of Cincinnati, Ohio, USA.

11 Hematology and Oncology Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

12 Department of Radiology, Shahid Rahnemoon Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

13 Mother and Newborn Health Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Abstract

Studies on the CXCL12 rs1801157 polymorphism show that this polymorphism is involved in development of breast cancer, but its specific relationships or effects are not consistent. The purpose of this meta-analysis was to investigate the association between CXCL12 rs1801157 polymorphism and susceptibility to breast cancer. PubMed, Scopus, Embase, the Cochrane Library, Web of Science, and CNKI were searched for eligible studies through February 01, 2023. A total of ten studies with 2093 cases and 2302 controls were included in this meta-analysis. Overall, there is a significant association between CXCL12 rs1801157 polymorphism and risk of breast cancer under the homozygote genetic model (AA vs. GG, OR= 1.350, 95% CI: 1.050-1.734, p= 0.019). Stratified by ethnicity showed a significant association in Caucasian women, but not among Asian and mixed populations. This meta-analysis confirms that CXCL12 rs1801157 polymorphism is related to breast cancer risk, especially among Caucasian women. However, well-designed large-scale studies are required to further evaluate the results.

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Asian Pacific Journal of Cancer Prevention
Volume 25, Issue 3
March 2024
Pages 767-776

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History

  • Receive Date: 23 September 2023
  • Revise Date: 09 December 2023
  • Accept Date: 02 March 2024

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