Document Type : Systematic Review and Meta-analysis
Authors
1
Department of Obstetrics and Gynecology, Firoozgar Hospital, Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran.
2
Department of Gynecologic Oncology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
3
Department of Obstetrics and Gynecology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4
Shahid Akbarabadi Cilinical Research Development Unit, Iran University of Medical Sciences, Tehran, Iran.
5
Department of Obstetrics and Gynecology, Atieh Hospital, Tehran, Iran.
6
Department of Radiation Oncology, Firoozgar Hospital, Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran.
7
Department of Obstetrics and Gynecology, Iranshahr University of Medical Sciences, Iranshahr, Iran.
8
General Practitioner, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
9
General Practitioner, Babol University of Medical Sciences, Babol, Iran.
10
Department of Cancer Biology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
11
Department of Radiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
12
Mother and Newborn Health Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
Background: Cervical cancer, globally, ranks as the runner-up among the most prevalent forms of cancer affecting women. The role of the tumor necrosis factor alpha (TNF-α) polymorphism in the susceptibility to cervical cancer has been a subject of interest. However, the current evidence regarding this association remains inconclusive. Methods: To address this uncertainty, eligible studies were systematically searched and retrieved from various databases including Cochrane Library, EMBASE, PubMed, Web of Science, CNKI, and Wanfang database. The search was conducted until September 01, 2023. The collected literature was then subjected to independent analysis by two authors. The pooled odds ratio along with the corresponding 95% confidence interval was calculated using different genetic models. Additionally, sensitivity and cumulative analyses were performed to assess the stability of the obtained results. Results: A total of 29 case-control studies involving 8850 cases and 9286 controls were included in the present analysis. The findings revealed that the TNF-α rs1800629 polymorphism increased the risk of cervical cancer under the allele genetic model (A vs. G: OR = 1.277, 95% CI = 1.104-1.477, P = 0.001) in the general population. Subgroup analysis based on ethnicity demonstrated that this polymorphism was associated with an increased risk of cervical cancer in Caucasian and African women, but not in Asians. Furthermore, subgroup analysis based on country of origin indicated a significant correlation between the TNF-α rs1800629 polymorphism and an increased risk of cervical cancer in American and Chinese women, but not in Iranian women. Conclusions: The findings from this meta-analysis suggest that the TNF-α rs1800629 polymorphism is a risk factor for cervical cancer in the general population, particularly in Caucasian and African women. However, further well-designed studies are warranted to validate these findings.
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