Document Type : Research Articles
Authors
1
Student of Research Committee, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran.
2
Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran.
3
Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Science, Tehran, Iran
4
Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
5
Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
6
Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
7
Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran.
Abstract
Objective: This study seeks to elucidate the association between HLA-A, HLA-B, and HLA-DRB1 alleles and their relative risk contributions to ALL within an Iranian cohort. Methods: Utilizing a robust case-control design, this research involved 71 ALL patients and 71 age and sex-matched healthy individuals. Genotyping of specified HLA alleles was performed using the advanced PCR-SSP technique. Results: Our findings reveal a marked increase in the prevalence of the HLA-DRB1*04 allele among patients diagnosed with ALL compared to the control group (P<0.027). Conversely, the alleles HLA-A*26 (P=0.025), HLA-A*33 (P=0.020), and HLA-DRB1*03 (P=0.035) were observed at significantly reduced frequencies within the patient population. Conclusion: Our findings highlight HLA-DRB1*04 as a potential genetic marker for increased susceptibility to ALL, while HLA-A*26, HLA-A*33, and HLA-DRB1*03 emerge as protective factors.
Keywords
Main Subjects
)