Mortality of Young Women due to Breast Cancer in Low, Middle and High-Income Countries: Systematic Literature Review and Meta-Analysis

E Silva, Juliana Dalcin Donini; Pedroso, Raissa Bocchi; Pelloso, Fernando Castilho; Carvalho, Maria Dalva De Barros; Santos, Thais Da Silva; Dutra, Amanda De Carvalho; Stevanato, Kely Paviani; Marques, Vlaudimir Dias; De Andrade, Luciano; Araújo, Daniela Cristina De Medeiros; Dos Santos, Lander; Pelloso Borghesan, Deise Helena; Ribeiro, Helena Fiats; Canparoto, Camila Wohlenberg; Teixeira, Jorge Juarez Vieira; Marques, Fernanda Hoffmann; Pelloso, Sandra Marisa

doi:10.31557/APJCP.2024.25.7.2219

Mortality of Young Women due to Breast Cancer in Low, Middle and High-Income Countries: Systematic Literature Review and Meta-Analysis

Document Type : Systematic Review and Meta-analysis

Authors

¹ Post Graduate Program in Health Science - Maringa State University, 87020-900, Maringá, Paraná, Brazil.

² Physician by the State Foundation for Health Care (FEAS), 81130-160, Curitiba, Paraná, Brazil.

³ Post Graduate Program in Bioscience and Physiopathology-Maringa State University, 87020-900, Maringá, Paraná, Brazil.

⁴ Inga University Center - Uningá, 87035-510, Maringá, Paraná, Brazil.

⁵ Post Graduate Program in Health Promotion - Unicesumar, 87050-900, Maringá, Paraná, Brazil.

10.31557/APJCP.2024.25.7.2219

Abstract

Objective: To identify the difference in breast cancer mortality rates among young women according to countries’ economic classification. Methods: A systematic literature review included retrospective studies on breast cancer mortality rates in women aged 20 to 49 years. Databases used were PubMed, Web of Science, Scopus, and Virtual Health Library, with articles selected in English, Portuguese, and Spanish. The study selection and analysis were conducted by two pairs of researchers. Data from 54 countries were extracted, including 39 high-income, 12 upper-middle-income, and 3 lower-middle-income countries. A meta-analysis was performed with the quantitative data from two studies. Results: Six articles met the inclusion criteria. Four were analyzed descriptively due to data diversity, and two were included in the meta-analysis. The pooled mortality rate for high-income countries was 10.2 per 100,000 women (95% CI: 9.8-10.6), while for upper-middle-income countries, it was 15.5 per 100,000 women (95% CI: 14.9-16.1). Lower-middle-income countries had a pooled mortality rate of 20.3 per 100,000 women (95% CI: 19.5-21.1). The decrease in mortality rates in high-income countries was statistically significant (p<0.05). Conclusion: Mortality rates for breast cancer among young women have decreased significantly in high-income countries but have increased in lower-income countries. This disparity underscores the impact of insufficient investment in preventive measures, health promotion, early diagnosis, and treatment on young women’s mortality in lower-income countries.

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