Type I or Type II Endometrial Carcinoma? Role of BRCA1 Immunohistochemistry

Document Type : Research Articles

Authors

1 Faculty of Medicine, Mansoura University, Mansoura, Egypt.

2 Medical Oncology Unit, Oncology Center, Mansoura University, Mansoura, Egypt.

Abstract

Objectives: Investigation of diagnostic and prognostic relevance of BRCA1 immunohistochemistry (IHC) in endometrial carcinoma. Methods: Ninty four specimens of endometrial carcinomas were evaluated. Full sections stained with hematoxylin & eosin were revaluated for assessment of tumor type, grade, myometrial, & lympho-vascular invasion (LVI). Tissue microarray blocks were constructed using the pencil tip method and immunostained with Anti-BRCA1 antibody. BRCA1 was correlated with clinicopathological parameters as well as disease free survival and overall survival. Results: There was a statistically significant difference (P=0.001) between serous and endometroid carcinomas regarding BRCA1 expression where most cases of serous carcinoma showed negative expression. No statistically significant difference was found between BRCA1 positive and negative cases regarding disease free survival (DFS) or overall survival. Serous histotype, high grade, advanced stage, and omental deposits were the parameters significantly associated with decreased DFS. Conclusion: Results of this study can support inclusion of BRCA1 IHC in a panel to differentiate both endometroid and serous carcinomas. The current study found no prognostic relevance for BRCA1 in terms of overall survival and disease-free survival. 

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Asian Pacific Journal of Cancer Prevention
Volume 25, Issue 7
July 2024
Pages 2311-2317

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History

  • Receive Date: 09 December 2023
  • Revise Date: 10 May 2024
  • Accept Date: 17 July 2024

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