Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in Penile Cancer in Thailand

Document Type : Research Articles

Authors

1 Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

2 Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

3 Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

4 Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Abstract

Background: Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important etiological factors for several cancers. This study aimed to determine the prevalence of HPV and EBV infection in penile cancer. Methods: Forty-three formalin-fixed paraffin-embedded penile cancer tissue samples were analyzed for the HPV-induced p16INK4A protein by immunohistochemistry and Epstein-Barr encoding region in situ hybridization. Demographic data and overall survival were analyzed. Results: The median age of patients was 59 years, ranging from 23 to 91 years old. Most of the tumors (86%) were located at the tip of the penis. HPV infection was positive in 12/43 (27.9%) patients. EBV infection was observed in 2/43 (4.6%) of cases and there was no co-infection detected in this cohort. Patients who had p16INK4A overexpression had a trend toward longer survival compared to those without; the median survival time of 104.4 vs 89 months, the hazard ratio of 0.48 (95% CI: 0.16-1.42, p = 0.173). Conclusions: One-third of penile cancer patients were positive for HPV-induced p16INK4A expression and there was a trend toward better survival in HPV-positive patients. EBV infection was infrequent in penile cancer in Thailand.

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Asian Pacific Journal of Cancer Prevention

Articles in Press, Accepted Manuscript
Available Online from 27 October 2024

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History

  • Receive Date: 08 April 2024
  • Revise Date: 27 July 2024
  • Accept Date: 15 October 2024

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