Document Type : Research Articles
Authors
1
Department of Occupational Health and Safety Engineering, School of Health, Alborz University of Medical Sciences, Karaj, Iran.
2
Research Center for Health, Safety and Environment, Alborz University of Medical Sciences, Karaj, Iran.
3
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
4
Persian Gulf and Oman Sea Ecological Research Organization, Iranian Fisheries Research Organization, Agricultural Research, Education and Extension Organization (AREEO) Bandar Abbas, Iran.
5
Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
6
School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
7
Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
Background and objective: Hepatocellular carcinoma (HCC) is recognized as one of the major public health problems and deadly malignancies worldwide. Today, the use of compounds of natural origin in the treatment of cancer and other diseases has been of interest to researchers. Marine compounds such as algae have anti-cancer effects. In addition, Sea algae have nutritional value. This research is designed to investigate the cytotoxic effects of Hypnea flagelliformis (H. flagelliformis) extracts (methanolic, diethyl ether and n-hexane) on HCC mitochondria. Material and Method: HCC was induced by diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in rats. Then, toxicity parameters were evaluated. Results: The results showed that all H. flagelliformis extracts (250, 500 and 1000 µg/ml) significantly caused toxicity in HCC mitochondria, and no effect on healthy mitochondria was reported. Conclusion: The results indicate that the use of H. flagelliformis along with selected drugs in the treatment of HCC can help in the treatment of this cancer.
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