Therapeutic Targeting of PARP Expression and Glycolysis Rate-Limiting Enzymes in Breast Cancer Patients

Document Type : Research Articles

Authors

Department of Chemistry, Faculty of Sciences, University of Al-Qadisiyah, Iraq.

Abstract

Background: Breast cancer is a heterogeneous disease characterized by diverse biochemical, histological, and clinical features. PARP1 and glycolysis rate-limiting enzymes play critical roles in cancer progression, making them promising therapeutic targets. Aim: This study aimed to evaluate the expression levels of PARP1 and key glycolytic enzymes (HK, PFK, and PK) in breast cancer patients and assess their potential as therapeutic indicators. Materials and Methods: A total of 120 participants (60 breast cancer patients and 60 healthy controls) were included in the study. Blood samples were collected to measure PARP1 expression and the levels of glycolytic enzymes using ELISA. Statistical analyses were performed to compare the two groups. Results: PARP1 expression and glycolytic enzyme levels (HK, PFK, and PK) were significantly higher in breast cancer patients compared to healthy controls (p < 0.0001). Conclusion: The overexpression of PARP1 and key glycolytic enzymes indicates their involvement in breast cancer progression and underscores their potential as therapeutic targets and biomarkers.

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Asian Pacific Journal of Cancer Prevention
Volume 26, Issue 2
February 2025
Pages 611-617

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History

  • Receive Date: 04 October 2024
  • Revise Date: 14 December 2024
  • Accept Date: 22 February 2025

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