Background: Antioxidants play a crucial role in mitigating oxidative stress associated with cancer progression. Lycium shawii is noted for its high content of antioxidants and anti-inflammatory compounds. Silver nanoparticles (AgNPs) hold a prominent position among the various nanoparticles synthesized and characterized to date. Objective: In this study, we aimed to synthesize and characterize AgNPs loaded with alcoholic extracts of Lycium shawii and evaluate their antioxidant effects in vivo. Methods: Thirty rats were randomly divided into five groups, with six rats in each group. Group 1 (Control) was administered 1 mL of normal saline orally via a stomach tube daily. Group 2 received 1 mL of AgNPs at a dosage of 100 mg/kg on the day of administration. Group 3 was treated with 1 mL/day of Acetamiprid at a dosage of 25 mg/kg. Group 4 was given AgNPs (100 mg/kg) for three weeks, followed by Acetamiprid (25 mg/kg) for an additional three weeks. Group 5 received Acetamiprid (25 mg/kg) for three weeks, followed by AgNPs (100 mg/kg). All treatments were administered daily, and serum levels of T-AOC, TOS, as well as the biomarkers AST, ALT, urea, and creatinine, were evaluated across all groups. Results: The results of the study demonstrated a significant increase in TOS, ALT, AST, urea, and creatinine, as well as a significant decrease in T-AOC (p ≤ 0.05) in Group 3 compared to Groups 1, 2, 4, and 5. Conclusion: The in vivo results demonstrate that AgNPs, especially when combined with Lycium shawii extracts, exhibit significant antioxidant properties, suggesting a protective role against oxidative damage. These findings support the therapeutic potential of AgNPs in cancer treatment and oxidative stress-related disorders. Future studies are needed to fully elucidate the molecular mechanisms underlying the observed antioxidant effects and to assess the long-term safety and efficacy of AgNPs in clinical applications.
Noory Fajer, A. , Nasser Hussein, M. and Sebri Abdulsaheb, Y. (2025). Antioxidant property of Silver Nanoparticles Loaded with Alcoholic Extraction of Lycium Shawii. Asian Pacific Journal of Cancer Prevention, 26(6), 2197-2204. doi: 10.31557/APJCP.2025.26.6.2197
MLA
Noory Fajer, A. , , Nasser Hussein, M. , and Sebri Abdulsaheb, Y. . "Antioxidant property of Silver Nanoparticles Loaded with Alcoholic Extraction of Lycium Shawii", Asian Pacific Journal of Cancer Prevention, 26, 6, 2025, 2197-2204. doi: 10.31557/APJCP.2025.26.6.2197
HARVARD
Noory Fajer, A., Nasser Hussein, M., Sebri Abdulsaheb, Y. (2025). 'Antioxidant property of Silver Nanoparticles Loaded with Alcoholic Extraction of Lycium Shawii', Asian Pacific Journal of Cancer Prevention, 26(6), pp. 2197-2204. doi: 10.31557/APJCP.2025.26.6.2197
CHICAGO
A. Noory Fajer , M. Nasser Hussein and Y. Sebri Abdulsaheb, "Antioxidant property of Silver Nanoparticles Loaded with Alcoholic Extraction of Lycium Shawii," Asian Pacific Journal of Cancer Prevention, 26 6 (2025): 2197-2204, doi: 10.31557/APJCP.2025.26.6.2197
VANCOUVER
Noory Fajer, A., Nasser Hussein, M., Sebri Abdulsaheb, Y. Antioxidant property of Silver Nanoparticles Loaded with Alcoholic Extraction of Lycium Shawii. Asian Pacific Journal of Cancer Prevention, 2025; 26(6): 2197-2204. doi: 10.31557/APJCP.2025.26.6.2197
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