Revolutionizing HER2-Positive Breast Cancer Treatment: Insights from the 47th San Antonio Breast Cancer Symposium on Trastuzumab Deruxtecan

Document Type : Editorials

Authors

1 Breast Health & Cancer Research Center, Iran University of Medical Sciences, Tehran, Iran.

2 Department of General Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

3 Department of General Surgery, Babol University of Medical Sciences, Mazandaran, Iran.

4 Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

5 Clinical Research Development Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Abstract

This editorial discusses the groundbreaking advancements in the treatment of HER2-positive breast cancer presented at the 47th San Antonio Breast Cancer Symposium, focusing on trastuzumab deruxtecan (T-DXd). T-DXd, an innovative antibody-drug conjugate, has shown significant improvements in progression-free survival (PFS) and overall survival (OS) compared to traditional chemotherapy, particularly in patients with HER2-positive metastatic breast cancer. Key studies, including DESTINY-Breast03 and DESTINY-Breast04, demonstrate T-DXd’s efficacy and safety across diverse populations, including those with HER2-low tumors and brain metastases. The editorial also highlights the importance of real-world applications, ongoing research into biomarkers, and the potential of combination therapies, such as T-DXd with pyrotinib. The findings suggest that T-DXd not only extends survival but also enhances health-related quality of life for patients, promising a transformative shift in treatment paradigms for HER2-positive breast cancer.

Keywords

Asian Pacific Journal of Cancer Prevention
Volume 26, Issue 8
August 2025
Pages 2695-2697

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History

  • Receive Date: 14 February 2025
  • Revise Date: 23 August 2025
  • Accept Date: 15 August 2025

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