The Effect of Resistance Training on Serum Levels of Lipid Profile and Liver Enzymes in Male Rat Undergoing Radiotherapy

Articles in Press

Document Type : Research Articles

Authors

1 Department of Sports Physiology and Pathology, Arak University, Arak, Iran.

2 Department of Radiotherapy and Medical Physics, Faculty of Para Medicine, Arak University of Medical Sciences and Khansari Hospital, Arak, Iran.

Abstract

Background: This study investigated the effects of resistance training on lipid profiles and liver enzyme levels in male rats exposed to x-ray radiation. Methods: In this experimental study, 24 eight-week-old Sprague Dawley rats (200-250g) were randomly assigned into four groups: healthy control, irradiated control, healthy resistance training, and irradiated resistance training. Irradiation was induced at a dose of 4 Gy on the whole body. The resistance training protocol was performed for ten weeks. Finally, blood serum was used to assess AST, ALT, ALP and testosterone, and lipid profile. Data were analyzed using ANOVA and Tukey’s post hoc test using SPSS-16 software at a 0.05 level of significance. Results: The results showed that radiation significantly increased serum levels of AST (169.3±2.4 ‏vs 131.1±2.4, P=0.001), ALT (75.6±3.6 vs 65.1±3.1, P=0.002), and ALP (503.5±83.1 ‏vs 370.3±66.9, P=0.034) between radiation control and healthy control groups. Also, no significant difference was observed between serum levels of AST (P=1.000) ALT (P=0.942), and ALP (P=0.925) in radiation resistance training and the healthy control groups. In addition, a significant increase was observed between radiation control and radiation resistance training groups in lipid profiles (P≥0.05). Also, no significant difference was observed between serum levels of TG (P=0.212) LDL-C (P=0.931), and HDL-C (P=0.992) in radiation resistance training and the healthy control groups. Conclusions: Our findings suggest that resistance training may improve lipid profiles and liver enzyme levels in male rats exposed to x-ray radiation.

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Asian Pacific Journal of Cancer Prevention

Articles in Press, Accepted Manuscript
Available Online from 13 September 2025

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History

  • Receive Date: 16 January 2025
  • Revise Date: 30 April 2025
  • Accept Date: 01 September 2025

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