Comparison of Dose-Volume Histograms of Three Whole Breast Radiotherapy Regimes: Conventional, Normal Hypofractionation and FAST-FORWARD Hypofractionation

Nabizadeh-Javan, Amir Hossein; Porouhan, Pezhman; Jalambadani, Zeinab; Javadinia, Seyed Alireza; Chaman, Reza; Dhawan, Gaurav; Sharma, Gunjan; Dhawan, Vikas; Ghahramani-Asl, Ruhollah

doi:10.31557/APJCP.2025.26.11.4109

Comparison of Dose-Volume Histograms of Three Whole Breast Radiotherapy Regimes: Conventional, Normal Hypofractionation and FAST-FORWARD Hypofractionation

Document Type : Research Articles

Authors

¹ Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.

² Department of Radiation Oncology, Vasee Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran.

³ Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.

⁴ Sri Guru Ram Das (SGRD), University of Health Sciences, Amritsar, India and Independent Consultant, Hartford, CT, United States.

⁵ Medical Physicist, Government Medical College, Amritsar, India.

⁶ Urologist, Commanding Officer, Field Hospital, Jammu and Kashmir, India.

⁷ Department of Medical Physics and Radiological Sciences, Faculty of Paramedicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

10.31557/APJCP.2025.26.11.4109

Abstract

Objective: This study aims to compare dose-volume histograms of three whole breast radiotherapy regimes there are: conventional radiotherapy (CRT), normal hypofractionation (NHRT) and FAST-FORWARD hypofractionation radiotherapy (FFRT). Methods: This retrospective single-center study was conducted in the radiotherapy department of Vasei Hospital in Sabzevar, Iran in 2024. The therapeutic dose for the chest/whole breast and regional lymph nodes was administered using CRT (50Gy/2Gy/25Fx), NHRT (42.56Gy/2.66Gy/16Fx), and FFRT (26Gy/5.2Gy/5Fx) regimens. Results: The results of this study showed no statistically significant difference in the average scores of PTV V95%, PTV V107-110%, conformity index, and homogeneity index among the CRT, NHRT and FFRT treatment regimens. However, the average scores of PTV Dmean, lung Vmean, and heart Vmean were significantly higher for CRT and NHRT relative to FFRT group. Conclusion: The CRT is not superior to the NHRT and FFRT regimes, and in some cases, especially NHRT, they can be used interchangeably in the unique conditions and crowded government medical centers to provide more treatment services to patients and lower financial burden to the healthcare system.

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